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Pagina 1 a partire dal 46 risultati
Corn oil ketogenic diet for children with intractable seizures.
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The ketogenic diet is a well-established, but relatively infrequently used, therapy for intractable seizures in children. Currently, the standard ketogenic diet is formulated using medium chain triglyceride (MCT) oil as its major caloric source. Cost, availability, and gastrointestinal side effects
Effects of organotin compounds on maximal electroshock seizure (MES) responsiveness in mice. II. Tricyclohexyltin and triphenyltin.
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Male mice (25-30 g) were injected (ip) with either 0, 3.5 X 10(-6), 17.5 X 10(-6), or 26.25 X 10(-6) mol/kg of either tricyclohexyltin bromide (TCT) or triphenyltin acetate (TPhT) in a corn-oil vehicle. The mice were tested for maximal electroshock seizure (MES) at 0.5, 4, 24, and 96 h following
Seizure thresholds in kindled animals are reduced by the pesticides lindane and endosulfan.
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Lindane and endosulfan are chlorinated hydrocarbon pesticides that bind to the gamma-aminobutyric-acidA (GABAA) receptor ionophore complex. We have previously demonstrated development of a persistent predisposition to the seizure-inducing properties of these pesticides following repeated
Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity.
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Methylcyclopentadienyl manganese tricarbonyl (MMT) is an organic manganese-containing compound which is used as an additive in unleaded gasoline. One neurotoxic effect of MMT in mice is seizure activity. In this study, seizures were observed in mice treated with MMT in propylene glycol or corn oil.
The persistence of kindled amygdaloid seizures in rats exposed to lindane.
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The persistence of the kindled seizure state produced during exposure to 5 mg/kg/day lindane was compared to that produced in nonexposed subjects. Persistence was evaluated at intervals of 2 weeks and 2 months. Rats were kindled on corn oil alone or corn oil + lindane until each rat exhibited a
Toluene exposure increases aminophylline-induced seizure susceptibility in mice.
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The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated. Mice were pretreated with an ip injection of corn oil or toluene (100-500 mg/kg) followed by a timed intravenous infusion of aminophylline at various time intervals to assess the seizure thresholds and
Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels.
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Toluene is one of the most widely used solvents. Electrophysiological studies indicated that this solvent directly affects various ligand gated ion channels including NMDA, GABA(A), nicotinic and glycine receptors. The effect of toluene on seizures induced by chemoconvulsants acting on these
Effects of hexachlorocyclohexane isomers on the acquisition of kindled seizures.
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The effects of three isomers (alpha, beta, gamma) of hexachlorocyclohexane on the acquisition and expression of kindled amygdaloid seizures were compared. Treatment with corn oil (vehicle) was compared with daily 5 mg/kg doses of the isomers for 15 days during kindling procedures. The results
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
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There is an increasing body of evidence that the central nervous system is affected by cholestatic liver disorders. Cholestasis has been shown to result in a decreased seizure propensity which is believed to be mediated by an increased opioidergic tone and nitric oxide (NO) signaling pathway. In
Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures.
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This study investigated the effects of two supplementary dietary oils (fish oil and corn oil) as parts of isocaloric/isoproteic diets on growth, brain fatty acid composition, and behavior in rat pups with recurrent seizures. Recurrent seizures were induced by injecting rat pups with
Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat.
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Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway
Impact of chlorpyrifos on health biomarkers of broiler chicks.
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The present study aimed to investigate the deleterious effects of chlorpyrifos (CPF) in experimentally exposed broiler birds. The experiment was carried out on one day old (n = 120) broiler chicks. The CPF was reconstituted in corn oil as vehicle (1 ml/kg) to obtain a final concentration of a single
A characterization of chemical kindling with the pesticide endosulfan.
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In a companion article (see this issue), the proconvulsant properties of the pesticide endosulfan in electrical kindling of the amygdala are described. In the present report, an evaluation of the chemical kindling properties of endosulfan is presented. Repeated administration (3 times per week for a
Developmental exposure to an environmental PCB mixture delays the propagation of electrical kindling from the amygdala.
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Developmental PCB exposure impairs hearing and induces brainstem audiogenic seizures in adult offspring. The degree to which this enhanced susceptibility to seizure is manifest in other brain regions has not been examined. Thus, electrical kindling of the amygdala was used to evaluate the effect of
Toxic effects of oral hexahydro-1,3,5-trinitro-1,3,5-triazine in the western fence lizard (Sceloporus occidentalis).
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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been widely used as an explosive in munition formulations, resulting in contamination of wildlife habitat on military installations. To estimate health effects for reptilian species, acute, subacute, and subchronic oral toxicity studies were
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