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simalikalactone d/malaria
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Larvicidal properties of simalikalactone D from Quassia africana (Simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae.
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BACKGROUND
Botanical and microbial insecticides have been increasingly used for the control of mosquito given their efficacy and documented nontoxic effects on non-target organisms. The discovery of new insecticides is imperative because of the development of resistance by the mosquitoes to the
Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae).
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French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known
Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).
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We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in
Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.
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OBJECTIVE
Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria, and if yes, set up a standard protocol for preparing the herbal tea.
METHODS
The leaf tea was extracted with methylene chloride and the organic extract was
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