tay-sachs disease/protease

Il collegamento viene salvato negli appunti

Scegli il tipo di ordinamento

6 risultati

A new form of residual hexosaminidase activity in infantile Tay Sachs disease fibroblasts.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

Fibroblast cell lines obtained from five patients with the early onset form of Tay Sachs disease (TSD) possess a species of beta-N-acetylhexosaminidase (Hex) which is more anionic than Hex B but which is stable to heating under conditions which completely inactivate Hex A. This species, which

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

GM2 gangliosidoses, including Tay-Sachs and Sandhoff diseases, are neurodegenerative lysosomal storage diseases that are caused by deficiency of β-hexosaminidase A, which comprises an αβ heterodimer. There are no effective treatments for these diseases; however, various strategies aimed at restoring

Tay-Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum-associated degradation.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay-Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of

Hexosaminidase A deficient adults: presence of alpha chain precursor in cultured skin fibroblasts.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

Cultured skin fibroblasts from hexosaminidase A deficient adults synthesize the alpha and beta chain precursors of beta-hexosaminidase (EC 3.2.1.30) of the same molecular weight as that synthesized by normal fibroblasts. However, the amount of the alpha chain precursor is greatly reduced. The alpha

Isolation and characterization of copia-type retrotransposons in Arabidopsis thaliana.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

We isolated two copia-type retrotransposons from Arabidopsis thaliana. We named these elements AtRE1 (Arabidopsis thaliana Retro Element 1) and AtRE2. Nucleotide sequence analysis revealed that both elements have long terminal repeats (LTRs), and that their internal sequences include one large open

Ginger DNA transposons in eukaryotes and their evolutionary relationships with long terminal repeat retrotransposons.

Solo gli utenti registrati possono tradurre articoli

Entra registrati

BACKGROUND In eukaryotes, long terminal repeat (LTR) retrotransposons such as Copia, BEL and Gypsy integrate their DNA copies into the host genome using a particular type of DDE transposase called integrase (INT). The Gypsy INT-like transposase is also conserved in the Polinton/Maverick

Unisciti alla nostra
pagina facebook

Herbal & Natural Medicine

Il database di erbe medicinali più completo supportato dalla scienza

Funziona in 55 lingue
Cure a base di erbe sostenute dalla scienza
Riconoscimento delle erbe per immagine
Mappa GPS interattiva - tagga le erbe sul luogo (disponibile a breve)
Leggi le pubblicazioni scientifiche relative alla tua ricerca
Cerca le erbe medicinali in base ai loro effetti
Organizza i tuoi interessi e tieniti aggiornato sulle notizie di ricerca, sperimentazioni cliniche e brevetti

Digita un sintomo o una malattia e leggi le erbe che potrebbero aiutare, digita un'erba e osserva le malattie ei sintomi contro cui è usata.
* Tutte le informazioni si basano su ricerche scientifiche pubblicate