4 risultati
OBJECTIVE
To observe the effect of tenuigenin (TEN) on aggregated amyloid beta-protein 1-40 (Abeta(1-40)-induced cytotoxicity of primary cultural cortical neurons in vitro.
METHODS
In order to establish neurotoxic model, the primary cultural rat cortical neurons were treated with 25 micromol x L(-1)
Amyloid beta-protein (A beta) is a pivotal pathological factor in Alzheimer's disease (AD). Tenuigenin, extracted from the Chinese herb Polygala tenuifolia, seems to ameliorate the reduction in cholinergic function on rat models induced by A beta. To examine this therapeutic effect, we tested
OBJECTIVE
Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Abeta from cultured cells. However, the mechanism underlying this effect and the active
OBJECTIVE
To explore the scavenging action of tenuigenin (TEN) on intracerebral amyloid β protein (Aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in Alzheimer's disease (AD) rats' brain.
METHODS
Aβ1-40 was injected into the right CA1 region hippocampus to establish the