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tenuigenin/necrosis
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4 risultati
Protective role of tenuigenin on sepsis-induced acute kidney injury in mice.
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Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the associated high mortality rate. Tenuigenin (TNG) is a natural product isolated from Polygala tenuifolia root, which possesses anti-inflammatory and anti-oxidant properties. The present study investigated
Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways.
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We aimed to explore the protective effect of tenuigenin (TNG) on lipopolysaccharide (LPS)-stimulated inflammatory responses in acute lung injury (ALI). Thus, we assessed the effects of TNG on the LPS-induced production of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in the culture
Tenuigenin protects dopaminergic neurons from inflammation-mediated damage induced by the lipopolysaccharide.
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BACKGROUND
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
OBJECTIVE
To study if tenuigenin (TEN), the main active component of Polygala tenuifolia, can protect dopaminergic neurons from
Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway.
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Tenuigenin (TGN), a major active component of polygala tenuifolia root, has been reported to have anti-inflammatory effect. In this study, we investigated the anti-neuroinflammatory effects of TGN on LPS-induced inflammation both in vitro and in vivo. The levels of tumor necrosis factor -α (TNF-α),
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