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Responsiveness of eosinophils to aeroallergens may be independent of atopic status.
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It has been reported that extracts from common aeroallergens directly activate eosinophils from non-allergic individuals, eliciting chemotaxis and degranulation. The aims of this study were to compare the reactivity of eosinophils from non-atopic and atopic individuals to airborne allergens, and to
Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins.
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BACKGROUND
With the exception of antigen-specific immunotherapy, current treatments for atopic diseases provide only symptomatic relief. Because of the increasing incidence of such diseases, the development of novel strategies and concepts for the treatment of allergies is urgently
Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.
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OBJECTIVE
The trace element zinc is essential for immune function and its regulation. Since zinc deficiency and allergic hyperresponsive reactions are often accompanied, the influence of zinc on allergen-induced cell growth, CD4+ regulatory T (Treg) cell numbers and cytokine expression during
CD4+ T cells have a key instructive role in educating dendritic cells in allergy.
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BACKGROUND
Dendritic cells (DCs) are central in allergy as regulators of the Th1/Th2 balance. We have recently demonstrated a unique transcriptional profile of DCs in patients with ongoing allergy compared with healthy subjects and shown that crosstalk between DCs and memory T cells affects the
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.
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Compared with DR and DQ, knowledge of the binding repertoires and specificities of HLA-DP alleles is somewhat limited. However, a growing body of literature has indicated the importance of DP-restricted responses in the context of cancer, allergy, and infectious disease. In the current study, we
Barrier responses of human bronchial epithelial cells to grass pollen exposure.
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The airway epithelium forms a physical, chemical and immunological barrier against inhaled environmental substances. In asthma, these barrier properties are thought to be abnormal. In this study, we analysed the effect of grass pollen on the physical and immunological barrier properties of
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