7 risultati
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity. Here, we report two newly characterised withanolides,
Four novel withanolide-type steroids named cilistols p, pm, p1 and u (1-4, respectively), were isolated from the leaves of Solanum cilistum. The respective structures were characterized by spectroscopic means as follows: cilistol p (1) was
The present work describes the evaluation of the antidepressant-like activity of the extract, fractions, and compounds obtained from the aerial parts of Solanum capsicoides. The methanolic extract (MESC) obtained by conventional maceration was partitioned with solvents of increasing polarities
Six withanolide-type steroids, named as cilistols a, b, d, q, g and f, respectively, were isolated from the leaves of Solanum cilistum. The major component among them, cilistol a, was characterized as (22R, 24S, 25R, 26R)-1-oxo-22, 26; 24, 25-diepoxy-17alpha, 26-dihydroxyergost-2,5-diene on the
Six new withanolide-type steroids, designated cilistols v, t, i, j, y and w (1-6, respectively), were obtained from the leaves of Solanum cilistum. Their respective structures were characterized by spectroscopic means as follows: Cilistol v (1) was
In addition to the known cilistol A, two new withanolides have been isolated from leaves and stem of Solanum sisymbiifolium, and assigned the structures 1-oxo-5,6; 22,26; 24,25-triepoxy-17,26-dihydroxyergost-2-ene and 1-oxo-22,26; 24,25-diepoxy-5,6,17,26-tetrahydroxy ergost-2-ene, namely
Previously, it has been shown that certain withanolides from Iochroma gesnerioides (Solanaceae) possess ecdysteroid antagonistic activity. Phytoecdysteroids (agonists) are widely distributed in the plant world, but solanaceous species have not been extensively examined for their presence. We have