Lactose, Sucrose & Corn Syrup Tolerance

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

הקישור נשמר בלוח

סטָטוּסהושלם

נותני חסות

University of British Columbia

ניסוי קליני: NCT01789307

BioSeek: NCT01789307

מילות מפתח

תַקצִיר

Lactose, one of the key nutrients in human milk may be critically important to infants for more reasons than being a source of energy. We are interested in understanding how lactose when compared to other sugars influences how nutrients, specifically macronutrients are handled after digestion and absorption. To date, there have been no studies looking at how fat and protein varies when lactose compared to other sugars is ingested. There may be metabolic advantages to considering lactose for nutrition support of premature infants rather than glucose or dextrose as is often used in intravenous feeds, or the corn syrup solids in lactose-free formulas. We hope the information from this study will provide new information on the unique aspects of lactose.

Hypothesis: The hypothesis is that providing carbohydrate as lactose:

1. minimizes the amount of carbohydrate that is converted into fat

2. enables a relatively constant metabolic state throughout feeding interval that avoids swings of high to low insulin, glucose, and fats.

תאריכים

אומת לאחרונה:	06/30/2014
הוגש לראשונה:	12/19/2012
ההרשמה המשוערת הוגשה:	02/07/2013
פורסם לראשונה:	02/11/2013
העדכון האחרון הוגש:	07/02/2014
עדכון אחרון פורסם:	07/03/2014
תאריך תחילת לימוד בפועל:	12/31/2012
תאריך סיום משוער משוער:	05/31/2013
תאריך סיום משוער ללימודים:	05/31/2013

מצב או מחלה

Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose

התערבות / טיפול

Dietary Supplement: corn syrup solids

Dietary Supplement: sucrose

שלב

קבוצות זרועות

זְרוֹעַ	התערבות / טיפול
Active Comparator: corn syrup solids corn syrup solids oral ingestion	Dietary Supplement: corn syrup solids oral ingestion 50 grams, 2 doses
Experimental: sucrose sucrose oral ingestion	Dietary Supplement: sucrose oral ingestion 50 grams, 2 doses

קריטריונים לזכאות

גילאים הזכאים ללימודים	19 Years ל 19 Years
מינים הזכאים ללימודים	Male
מקבל מתנדבים בריאים	כן
קריטריונים	Inclusion Criteria: - male - at least 19 years of age - body mass index (BMI) between 18.5 and 25 - fasting blood glucose level < 6.1 mmol/L (110 mg/dL) measured by glucometer on the day of the study and - comfortable speaking, reading and understanding English - comfortable drinking at least one cup (250 ml) of milk - non-smoking Exclusion Criteria: - not willing to provide blood samples, have - impaired lactose or glucose tolerance, - pre-diabetes, diabetes mellitus and any other endocrine disorder, - coronary heart disease, liver function test abnormalities or any chronic disease - routinely take medications, including aspirin, cyclooxygenase-2 inhibitors, statins and fish oil - consuming more than 1 alcoholic drink per day

תוֹצָאָה

מדדי תוצאות ראשוניים

1. Postprandial changes in plasma insulin, glucagon, triglycerides and amino acids. [6 hours]

Area under the curve changes in the outcome measures following oral ingestion.

אמצעי תוצאה משניים

1. Postprandial changes in plasma fatty acids. [6 hours]

Area under the curve analyses of changes in plasma fatty acids following oral ingestion

Lactose, Sucrose & Corn Syrup Tolerance

מילות מפתח

lactose

sucrose

גלוקוז

carbohydrate

zea

תירס