Boron Neutron Capture Therapy (BNCT) as Treatment of Glioblastoma

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

הקישור נשמר בלוח

סטָטוּסהופסק

נותני חסות

Boneca Corporation

ניסוי קליני: NCT00115453

BioSeek: nct00115453

מילות מפתח

תַקצִיר

Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique that is based on the principle of irradiating boron atoms with neutrons. When neutrons have relatively low energy, boron atoms that have been targeted to cancerous tissue using a suitable boron carrier (an amino acid derivative called BPA, boronophenylalanine) will capture the neutrons. As a result from the neutron capture the boron atoms will split into two, producing helium and lithium ions. The helium and lithium ions, in turn, have only a short pathlength in tissue (about 5 micrometers) and will deposit their cell damaging effect mainly within the tumor provided that the boron carrier (BPA) has accumulated in the tumor. In practice, the study participants will receive BPA as an approximately 2-hour intravenous infusion, following which the tumor is irradiated with low energy (epithermal) neutrons obtained from a nuclear reactor at the BNCT facility. BNCT requires careful radiation dose planning, but neutron irradiation will last approximately only for one hour. In this study BNCT is given only once. The study hypothesis is that glioblastoma tissue may accumulate the boron carrier compound, and glioblastoma might respond to BNCT.

תיאור

This is a single BNCT-facility, non-randomized, non-comparative, prospective, open-label, phase I/II trial to determine the value of BNCT in the treatment of subjects who have undergone surgery for glioblastoma, but glioblastoma has not been treated with radiation therapy or chemotherapy. The neutron irradiation site is the FiR 1 reactor site, located at Otaniemi, Espoo, Finland, about 6 kilometers from the Helsinki University Central Hospital, Helsinki, where patient evaluation and post-irradiation care will take place.

BPA is infused as a fructose complex (BPA-F) into a peripheral vein over 2 hours prior to neutron irradiation. Blood samples will be taken before starting the BPA infusion, and thereafter at 20 to 40 minute intervals during the infusion, following infusion, and after delivering neutron irradiation to monitor the blood boron concentration. The blood samples will be analyzed for boron to estimate the average blood boron level during neutron irradiation. The first 12 patients are treated using a BPA dose of 290 mg/kg, following which the dose of BPA is increased stepwise to 500 mg/kg, provided that unacceptable toxicity will not occur.

All patients will be evaluated for response using CT or magnetic resonance imaging (MRI).

תאריכים

אומת לאחרונה:	07/31/2008
הוגש לראשונה:	06/21/2005
ההרשמה המשוערת הוגשה:	06/21/2005
פורסם לראשונה:	06/22/2005
העדכון האחרון הוגש:	08/13/2008
עדכון אחרון פורסם:	08/17/2008
תאריך תחילת לימוד בפועל:	04/30/1999
תאריך סיום משוער משוער:	07/31/2008
תאריך סיום משוער ללימודים:	07/31/2008

מצב או מחלה

Glioblastoma

התערבות / טיפול

Radiation: A

שלב

שלב 1/שלב 2

קבוצות זרועות

זְרוֹעַ	התערבות / טיפול
Experimental: A Active treatment arm.	Radiation: A Boronophenylalanine is infused into a peripheral vein prior to neutron irradiation.

קריטריונים לזכאות

גילאים הזכאים ללימודים	18 Years ל 18 Years
מינים הזכאים ללימודים	All
מקבל מתנדבים בריאים	כן
קריטריונים	Inclusion Criteria: - Histologically confirmed glioblastoma multiforme - Supratentorial location - At least 30% of the tumor volume has been removed at craniotomy as judged from a pre/perioperative MRI - Ability to understand the concept of investigational therapy - Tolerates dexamethasone treatment - Adequate anti-epileptic medication - BNCT can be delivered within 6 weeks from the date of brain surgery - A written informed consent Exclusion Criteria: - Age less than 18 or greater than 75 - The tumor infiltrates into the optic chiasm or into the deep parts of the brain prohibiting delivery of an adequate radiation dose with BNCT - Prior radiation therapy to the brain - Prior chemotherapy, immunotherapy, or gene therapy - Karnofsky performance score <70 - Severe cardiac, liver, or kidney failure - Severe infection - A cardiac pace-maker, or a metal implant in the head and neck region that will prohibit MRI examination - Pregnancy or lactation - Phenylketonuria

תוֹצָאָה

מדדי תוצאות ראשוניים

1. safety [3 years]

אמצעי תוצאה משניים

1. tumor response [one year]

2. effect on brain tissue [3 years]

Boron Neutron Capture Therapy (BNCT) as Treatment of Glioblastoma

מילות מפתח

alpha fructose

סרטן

גליובלסטומה מולטיפורמה

boron

fructose

כימותרפיה