Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect
מילות מפתח
תַקצִיר
תאריכים
אומת לאחרונה: | 04/30/2017 |
הוגש לראשונה: | 04/29/2017 |
ההרשמה המשוערת הוגשה: | 05/07/2017 |
פורסם לראשונה: | 05/08/2017 |
העדכון האחרון הוגש: | 05/07/2017 |
עדכון אחרון פורסם: | 05/08/2017 |
תאריך תחילת לימוד בפועל: | 05/01/2017 |
תאריך סיום משוער משוער: | 07/30/2017 |
תאריך סיום משוער ללימודים: | 08/30/2017 |
מצב או מחלה
התערבות / טיפול
Drug: Essential oils (Listerine Mentol)
Drug: Alcohol free essential oils
Other: Water
שלב
קבוצות זרועות
זְרוֹעַ | התערבות / טיפול |
---|---|
Active Comparator: Essential oils (Listerine Mentol) a single mouthwash with 20 ml of essential oils for 30 seconds
20 ml rinses for 30 seconds with essential oils/2 times daily (1/0/1). | Drug: Essential oils (Listerine Mentol) all subjects will perform all interventions of all arms |
Placebo Comparator: Water a single mouthwash with 20 ml of sterile water for 30 seconds
20 ml rinses for 30 seconds with sterile water/2 times daily (1/0/1). | Other: Water all subjects will perform all interventions of all arms |
Experimental: Alcohol free essential oils a single mouthwash with 20 ml of alcohol free essential oils for 30 seconds
20 ml rinses for 30 seconds with alcohol free essential oils/2 times daily (1/0/1). | Drug: Alcohol free essential oils all subjects will perform all interventions of all arms |
קריטריונים לזכאות
גילאים הזכאים ללימודים | 20 Years ל 20 Years |
מינים הזכאים ללימודים | All |
מקבל מתנדבים בריאים | כן |
קריטריונים | Inclusion Criteria: - Systemically healthy adults. - Minimum of 24 permanent teeth. - No gingivitis (Community Periodontal Index score = 0). - No periodontitis (Community Periodontal Index score = 0). - Absence of untreated caries. Exclusion Criteria: - Smoker or former smoker. - Presence of dental prostheses. - Presence of orthodontic devices. - Antibiotic treatment or routine use of oral antiseptics in the previous 3 months. - Presence of any systemic disease that could alter the production or composition of saliva. |
תוֹצָאָה
מדדי תוצאות ראשוניים
1. Change in the Bacterial viability (%) (substantivity) [Baseline, 30 seconds, 1 hour, 3 hours, 5 hours and 7 hours after the single application]
2. Bacterial viability (%) (antiplaque effect) [10 hours after the last mouthwash]
3. Change in the Biofilm Thickness (Microns) (substantivity) [baseline, 30 seconds, 1 hour, 3 hours, 5 hours and 7 hours after the single application]
4. Biofilm Thickness (Microns) (Antiplaque effect) [10 hours after the last mouthwash]
5. Covering Grade (%) (antiplaque effect) [10 hours after the last mouthwash]