Nutrition in Gastrointestinal Tumors
מילות מפתח
תַקצִיר
תיאור
Malnutrition and sarcopenia are common complications in patients with malignant diseases of the gastrointestinal tract. During chemotherapy there is a high risk of further impairment of nutritional status due to anorexia, nausea, emesis and other gastrointestinal conditions that adversely impact food assimilation or absorption. Findings on changes of nutritional status during chemotherapy are scarce but of paramount importance for adequate nutrition therapy. Therefore, this study aims to provide a detailed description of changes in nutritional status of patients with a malignant condition of the gastrointestinal tract during chemotherapy.
תאריכים
| אומת לאחרונה: | 06/30/2020 |
| הוגש לראשונה: | 06/28/2020 |
| ההרשמה המשוערת הוגשה: | 07/12/2020 |
| פורסם לראשונה: | 07/16/2020 |
| העדכון האחרון הוגש: | 07/12/2020 |
| עדכון אחרון פורסם: | 07/16/2020 |
| תאריך תחילת לימוד בפועל: | 06/24/2020 |
| תאריך סיום משוער משוער: | 09/29/2022 |
| תאריך סיום משוער ללימודים: | 09/29/2022 |
מצב או מחלה
התערבות / טיפול
Other: No intervention - observational study only
שלב
קבוצות זרועות
| זְרוֹעַ | התערבות / טיפול |
|---|---|
| Initial Diagnosis Patients with initial diagnosis of a malignant condition of the gastrointestinal tract planned to receive cytostatic treatment. | |
| Ongoing Cytostatic Treatment Patients with a malignant condition of the gastrointestinal tract already receiving cytostatic treatment. |
קריטריונים לזכאות
| גילאים הזכאים ללימודים | 18 Years ל 18 Years |
| מינים הזכאים ללימודים | All |
| שיטת דגימה | Non-Probability Sample |
| מקבל מתנדבים בריאים | כן |
| קריטריונים | Inclusion Criteria: - Patients with initial diagnosis of a malignant condition of the gastrointestinal tract planned to receive cytostatic treatment. - ongoing cytostatic treatment of a known malignant condition of the gastrointestinal tract Exclusion Criteria: - pregnancy - history of any other malignant tumor disease - inability to provide consent |
תוֹצָאָה
מדדי תוצאות ראשוניים
1. Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition criteria (GLIM criteria) [3 months after study enrollment]
אמצעי תוצאה משניים
1. Prevalence of Malnutrition According to the European Society for Clinical Nutrition and Metabolism criteria (ESPEN criteria) [3 months after study enrollment]
2. Skeletal Muscle Mass [3 months after study enrollment]
3. Fat Free Mass [3 months after study enrollment]
4. Fat Mass [3 months after study enrollment]
5. Total Body Water [3 months after study enrollment]
6. Extracellular Water [3 months after study enrollment]
7. Phase Angle [3 months after study enrollment]
8. Body Weight [3 months after study enrollment]
9. Height [3 months after study enrollment]
10. Body Mass Index [3 months after study enrollment]
11. Waist Circumference [3 months after study enrollment]
12. Hip Circumference [3 months after study enrollment]
13. Waist-to-Hip Ratio [3 months after study enrollment]
14. Upper Arm Circumference [3 months after study enrollment]
15. Triceps Skinfold Thickness [3 months after study enrollment]
16. Muscle Strength [3 months after study enrollment]
17. Muscle Function [3 months after study enrollment]
18. Sarcopenia According to the European Working Group on Sarcopenia in Older People 2 criteria (EWGSOP2 criteria) [3 months after study enrollment]
19. Energy Intake [3 months after study enrollment]
20. Protein Intake [3 months after study enrollment]
21. Carbohydrate Intake [3 months after study enrollment]
22. Fat Intake [3 months after study enrollment]
23. Dietary Fiber Intake [3 months after study enrollment]
24. Physical Activity [3 months after study enrollment]
25. Complete Blood Count [3 months after study enrollment]
26. Albumin [3 months after study enrollment]
27. Aspartate Transaminase [3 months after study enrollment]
28. Alanine Aminotransferase [3 months after study enrollment]
29. Gamma-glutamyl Transferase [3 months after study enrollment]
30. Bilirubin [3 months after study enrollment]
31. Creatinine [3 months after study enrollment]
32. Urea [3 months after study enrollment]
33. C-reactive Protein [3 months after study enrollment]
34. Plasma Metabolome [3 months after study enrollment]
35. Plasma Transcriptome [3 months after study enrollment]
36. Intestinal Microbiome [3 months after study enrollment]
