pachyonychia congenita

Pachyonychia congenita (often abbreviated as 'PC') is a rare group of autosomal dominant skin disorders that are caused by a mutation in one of five different keratin genes. Pachyonychia congenita is often associated with thickened toenails, plantar keratoderma, and plantar pain.

Pachyonychia congenita is characterized by a clinical triad present in 97% of people with PC by the time they turn 10 years old:

Plantar pain that may require some patients to use wheelchairs, canes, crutches, and pain medications ...