4 תוצאות
The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS). Here, we show that under
A cDNA clone containing a fructose-1,6-bisphosphate aldolase (ALD) gene, designated ClAldC, was isolated from a medicinal plant Codonopsis lanceolata. ClAldC is predicted to encode a precursor protein of 358 amino acid residues, and its sequence shares high degrees of homology with a number of other
OBJECTIVE
Recent translational studies in osteosarcoma are discussed with the purpose to shed light on the new molecular therapeutic targets.
RESULTS
The genetic aberrations of vascular endothelial growth factor (VEGF), mammalian target of rapamycin, Wnt signaling pathway, the inactivation of p53,
Fructose is a major component of dietary sugar and its overconsumption exacerbates key pathological features of metabolic syndrome. The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C, generated through mutually exclusive alternative