Eupatorin is a naturally occurring flavone that inhibits cell proliferation in human tumor cells. Here we demonstrate that eupatorin arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and
An aqueous ethanol extract of Eupatorium altissimum L. (Compositae) showed confirmed activity in the P-388 lymphocytic leukemia assay in mice, and the chloroform solubles showed both cytotoxic activity in the 9KB carcinoma of the nasopharynx cell culture assay and antitumor activity in the P-388