The invention relates to a peptide compound and its pharmaceutical composition for inhibiting platelet aggregation and preventing/treating thrombogenic diseases. The invention develops pentapeptides and hexapeptides derived from snake venom C-type lectin-like proteins (CLPs) fragments, which can inhibit platelet aggregation and have antithrombotic activity without hemorrhagic tendency. Accordingly, they can be used as potential agents for the prevention and therapy of thrombogenic diseases.

NATIONAL TAIWAN UNIVERSITY

Peptide compounds for inhibitions of platelet aggregation

Huang; Tur-Fu

Chang; Chien-Hsin

Chung; Ching-Hu

Peptide compounds for inhibition of platelet aggregation

The somatostatin analog L-363,586 is a cyclic hexapeptide having the structure; cyclo-(N-methyl-Ala-Tyr-d-Trp-Lys-Val-Phe). L-363,586 has been found to be useful for inducing gastric cytoprotection via a mechanism not involving the inhibition of gastric acid secretions. Specific therapeutic utilities include, erosive gastritis, erosive esophagitis, inflammatory bowel disease and ethanol induced hemorrhagic gastric erosions.

hexapeptide/דימום

Peptide compounds for inhibitions of platelet aggregation

Peptide compounds for inhibition of platelet aggregation

Gastric cytoprotection with L-363,586

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע