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hexapeptide/השמנת יתר חולנית

הקישור נשמר בלוח
מאמריםניסויים קלינייםפטנטים
עמוד 1 מ 24 תוצאות
Hexarelin (Hex) is a new synthetic hexapeptide with potent growth hormone (GH)-releasing activity in both animals and men. We evaluated the GH response to a maximal dose of Hex (2 micrograms/kg iv) and GH-releasing hormone (GHRH) (1-29, 1 microgram/kg iv) in 45 short normal children (24 males and 21

Effects of coadministered growth hormone (GH)-releasing hormone and GH-releasing hexapeptide on maladaptive aspects of obesity in Zucker rats.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The purpose of this study was to determine the effect of chronic pharmacological stimulation of the pituitary gland on GH hyposecretion and other maladaptive aspects of obesity. Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6;

Somatotrope responsiveness to Hexarelin, a synthetic hexapeptide, is refractory to the inhibitory effect of glucose in obesity.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Both spontaneous and stimulated growth hormone (GH) secretion is reduced in obesity, in which state insensitivity to the inhibitory effect of hyperglycemia also has been reported. To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7

Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Neuromedin U (NMU) are bioactive peptides with a common C-terminal heptapeptide sequence (FLFRPRN-amide, 1a) among mammals, which is responsible for receptor activation, namely NMU receptor types 1 (NMUR1) and 2 (NMUR2). Among the various physiological actions of NMU, the anorexigenic effect has

Failure of pancreatic polypeptide release in congenitally obese mice.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Obesity can be reversed in ob/ob mice by parabiosis to lean littermates, by islet transplantation, and by injection of pancreatic polypeptide. These observations suggest that obese mice have functioning satiety centers but lack a circulating satiety factor of pancreatic origin which could be
Growth hormone (GH) secretion in response to all provocative stimuli is decreased in patients with obesity. Recently, we found that the combined administration of GH-releasing hormone (GHRH) and the hexapeptide GH-releasing peptide-6 (GHRP-6) induced a large increase in plasma GH levels. To gain
GH secretagogues (GHS) possess potent GH-releasing activity but also stimulate PRL, ACTH and cortisol (F) secretion. To further clarify the endocrine activities of GHS, in 9 obese patients, 9 patients with Cushing's disease and 14 controls we studied the ACTH, F, GH and PRL responses to hexarelin

Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6).

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Growth hormone (GH) secretion is regulated by a complex system of central and peripheral signals. Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. In the present work the mechanism of action of GHRP-6 has been

Impairment of GH responsiveness to GH-releasing hexapeptide (GHRP-6) in Prader-Willi syndrome.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The aim of this study was to evaluate the GH-releasing activity of a synthetic hexapeptide, GHRP-6, in the Prader-Willi syndrome (PWS). Sixteen PWS patients (7 males and 9 females, aged 12.7-38.3 yr), 15 with essential obesity (OB) (7 males and 8 females, aged 12.9-42.9 yr), and 8 short normal

Pancreatic polypeptide and other hormones in pancreas of obese (ob/ob) mice.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The insulin, glucagon, somatostatin and pancreatic polypeptide content of acid-ethanol extracts of pancreas from lean and obese (ob/ob) mice of various ages was determined by radioimmunoassay. Rat and mouse pancreatic polypeptide react weakly with antibodies to avian, bovine and canine pancreatic

Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker rats.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Genetically obese male Zucker rats have an impaired secretion of GH, coupled to hyperinsulinemia, hyperlipidemia and glucose intolerance. The aim of this study was to evaluate whether a chronic treatment with hexarelin, a synthetic enkephalin-derived hexapeptide with a potent GH-releasing activity,

Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matching analysis program. We find that the viral polyprotein shares numerous hexapeptides with the

Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Cholecystokinin (CCK) is a 33-amino acid peptide with multiple functions in both the central nervous system (via CCK-B receptors) and the periphery (via CCK-A receptors). CCK mediation of satiety via the A-receptor subtype suggest a role for CCK in the management of obesity. The carboxy terminal

Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Extensive structure-activity relationship studies utilizing a beta-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (3), led to identification of a series of novel MC-4R selective disulfide-constrained hexapeptide analogs including

Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The recent emergence of obesity as a major health threat in the industrialized world has intensified the search for novel and effective pharmacologic treatment. The proopiomelanocortin (POMC)-melanocortin 4 receptor (MC4R) axis has been shown to regulate food intake and energy homeostasis and is
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