Groups of immature and mature mice were treated once with DMBA by oral or intraperitoneal route, and the subsequent bilateral sequence of ovarian changes leading to the development of unilateral granulosa cell tumour was studied.Early post-treatment changes included disappearance of oocytes and
GnRH has been suggested to participate in corpus luteum function. Here we studied the expression of GnRH mRNA and peptide in two models of rat luteinized tissues: ovarian cells from PMSG-hCG treated prepubertal rats (SPO) and from intrasplenic ovarian tumors (Luteoma). A GnRH autoregulatory effect