monomethyl ether/ניוון ביולוגיה

הקישור נשמר בלוח

מאמריםניסויים קלינייםפטנטים

בחר סוג מיון

עמוד 1 מ 33 תוצאות

The ultrastructure and reversibility of testicular atrophy induced by ethylene glycol monomethyl ether (EGME) in the rat.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Inhalation exposure to 300 ppm ethylene glycol monomethyl ether (EGME) for 3 days produced degenerative changes in spermatocytes of pachytene and meiotic division at spermatogenic stage XIV in rats. However, a wide range of germ cell types including spermatogonia was affected and the stage-specific

The inhibin B response to testicular toxicants ethylene glycol monomethyl ether or dibromoacetic acid in male rats.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND This study was conducted as part of an ILSI-HESIconsortium effort to assess the utility of circulating inhibin B as an early biomarker of testicular toxicity in rats. METHODS Two known testicular toxicants were selected for use in this study: ethylene glycol monomethyl ether (EGME) and

Fetal hematopoietic alterations after maternal exposure to ethylene glycol monomethyl ether: prolymphoid cell targeting.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Ethylene glycol monomethyl ether (EGME), which is extensively used in the chemical industries, has been associated with hematologic disorders in both humans and experimental animals. EGME is metabolized to the active compound methoxy-acetic acid (MAA), which readily crosses the placenta and impairs

Immunological studies in B6C3F1 mice following exposure to ethylene glycol monomethyl ether and its principal metabolite methoxyacetic acid.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Exposure to glycol ethers has been associated with adverse effects in laboratory animals including thymus atrophy and mild leukopenia. These effects may involve depletion of immunoresponsive cells. This study examined possible alterations in immune function and host resistance of B6C3F1 mice

The effects of ethylene glycol monomethyl ether on testicular histology in F344 rats.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Ethylene glycol monomethyl ether (EGME) has been found to produce testicular atrophy in experimental rodents. The studies that follow were designed to determine the testicular cell type(s) most susceptible to EGME administration. For histologic studies, F344 rats were gavaged with 150 mg/kg/day of

Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 27). Repeated toxicity study on ethylene glycol monomethyl ether for 2 and 4 weeks to detect effects on male reproductive organs in rats.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

As part of a collaborative project to determine the minimum administration period to detect compound effects on male reproductive organs in Sprague-Dawley (Crj:CD(SD)) male rats, 6- and 8-week-old rats were administered ethylene glycol monomethyl ether (EGME) daily at 100 and 200 mg/kg/day for 2

The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The effects of a single inhalation exposure to the rat of the saturated vapours derived from four ethylene glycol monoalkyl ethers have been investigated. No effects on the testis were observed following exposure to ethylene glycol isopropyl ether (EG ISOPE) and ethylene glycol butyl ether (EGBE),

Comparative effects of ethylene glycol and ethylene glycol monomethyl ether exposure on hematopoiesis and histopathology in B6C3F1 mice.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Ethylene Glycol (EG) or Ethylene Glycol Monomethyl Ether (EGMME) was administered by gavage to both sexes of B6C3F1 mice for 4 consecutive days at total doses of 200, 400, and 1000 mg/kg body weight. Bone marrow parameters were examined on days 1, 5, and 14 after the final treatment. Exposure to EG

A cross-sectional study of ethylene glycol monomethyl ether process employees.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Human exposures to ethylene glycol monomethyl ether have been associated with hematological and neurological abnormalities. Recent animal toxicology studies have also reported testicular atrophy. To determine whether employees potentially exposed to ethylene glycol monomethyl ether during

Transcriptional profile of ethylene glycol monomethyl ether-induced testicular toxicity in rats.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

To clarify the molecular mechanism of ethylene glycol monomethyl ether (EGME)-induced testicular toxicity, the potential for EGME-related changes in transcript levels of genes including spermatocyte-specific genes was evaluated in the testis of rats given single dosing of EGME at 200, 600, or 2000

Assessment of adult and neonatal reproductive parameters in Sprague-Dawley rats exposed to propylene glycol monomethyl ether vapors for two generations.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

This study evaluated propylene glycol monomethyl ether (PGME) in a rat 2-generation reproduction study, which included non-traditional study end points, such as sperm count and motility, developmental landmarks, estrous cyclicity, and weanling organ weights. Groups of 30 male and 30 female

Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Kinase activities were previously proposed to be central to germ cell apoptosis induced by ethylene glycol monomethyl ether (EGME) and its active metabolite methoxyacetic acid (MAA). We evaluated the role of tyrosine kinase pp60(c-src) in control and EGME-treated adult rat testis in vivo, as well as

Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

A series of inhalation studies with propylene glycol monomethyl ether (PGME) vapor were undertaken to characterize its subchronic toxicity in mice and chronic toxicity/oncogenicity in rats and mice. Groups of male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 300, 1,000, or 3,000

Effect of heat treatments on stability of altemariol, alternariol monomethyl ether and tenuazonic acid in sunflower flour.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

A study was carried out to evaluate the effect of heat treatment on the stability of alternariol (AOH), alternariol monomethyl ether (AME) and tenuazonic acid (TeA) in sunflower flour and the effectiveness of this treatment by a biological assay in rats. The concentrations of AOH and AME remained

Comparative aspects of the reproductive toxicology by inhalation in rats of ethylene glycol monomethyl ether and propylene glycol monomethyl ether.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

This study was designed to provide a rapid assessment of the effect of two glycol ethers on some aspects of reproduction in the rat. Exposure was by inhalation at 100 and 300 ppm (EGME) and 200 and 600 ppm (PGME) for 6 hr/day. The study was in two parts: (a) Pregnant females were exposed on Days 6

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