OBJECTIVE
To test the hypothesis that the effects of estrogen reduction on uterine leiomyoma regression are mediated through changes in cell density or the extracellular matrix.
METHODS
Uterine myomas were obtained from 20 women who had received randomly either the GnRH agonist leuprolide acetate
Forty eight human uteri including normal group (16 cases), adenomyosis group (5 cases) and myoma group (27 cases) were studied to clarify the pathogenesis of uterine leiomyomas on the viewpoint of the collagen metabolism. The leiomyomas in the myoma group were histologically divided into the three