Bioavailability of Xanthones From Mangosteen
キーワード
概要
説明
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp of mangosteen fruit is used in traditional medicine to treat inflammation, infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family of polyphenols referred to as xanthones. Since its introduction into the United States, juices and products containing mangosteen fruit have become a top-selling botanical dietary supplement. This commercial success largely has been the result of aggressive marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen juice in adult human subjects. After an overnight fast of at least 10h, male and female subjects were admitted to the Ohio State University Clinical Research Center. Volunteers ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and 1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit after the 8h collection, refraining from mangosteen containing products until final collection of blood at 24h. Urine was collected for the 24 test period.
日付
最終確認済み: | 07/31/2011 |
最初に提出された: | 08/25/2011 |
提出された推定登録数: | 08/25/2011 |
最初の投稿: | 08/28/2011 |
最終更新が送信されました: | 08/30/2011 |
最終更新日: | 09/01/2011 |
実際の研究開始日: | 10/31/2010 |
一次完了予定日: | 10/31/2010 |
研究完了予定日: | 01/31/2011 |
状態または病気
段階
アームグループ
腕 | 介入/治療 |
---|---|
Females ingesting mangosteen juice | |
Males ingesting mangosteen juice |
適格基準
研究の対象となる年齢 | 18 Years に 18 Years |
研究に適格な性別 | All |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - 5 female - 5 male - body mass index = 30 - normal renal function - non-smoking Exclusion Criteria: - smokers - acute or chronic diseases - history of gastrointestinal diseases - >/= 10% weight loss - dietary or herbal supplement within 6 months of study - pregnancy |
結果
主な結果の測定
1. Xanthones in urine [0-24 hours]
二次的な結果の測定
1. Xanthones in sera [0-24 hours]