Blackberry Intake and Biomarkers of Cancer Risk
キーワード
概要
日付
| 最終確認済み: | 06/30/2011 |
| 最初に提出された: | 01/23/2011 |
| 提出された推定登録数: | 02/08/2011 |
| 最初の投稿: | 02/09/2011 |
| 最終更新が送信されました: | 07/14/2011 |
| 最終更新日: | 07/17/2011 |
| 実際の研究開始日: | 12/31/2010 |
| 一次完了予定日: | 03/31/2011 |
| 研究完了予定日: | 03/31/2011 |
状態または病気
介入/治療
Other: Blackberries
Other: Gelatin
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Placebo Comparator: Gelatin | Other: Gelatin 300 g gelatin per day for 5 days |
| Experimental: Blackberries | Other: Blackberries 300 g blackberries daily for 5 days |
適格基準
| 研究の対象となる年齢 | 40 Years に 40 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Non-smoking men and women - Aged 40-75 - BMI 19-38 kg/m2 Exclusion Criteria: - Younger then 40 ears old or older than 75 years old - BMI less than 19 or greater than 38 - Use of blood-thinning medications such as warfarin, dicumarol, or anisinidione - Presence of kidney disease, liver disease, gout, certain cancers, untreated thyroid, gastrointestinal, other metabolic diseases or malabsorption syndromes - Type 2 diabetes requiring the use of oral antidiabetic agents or insulin - Fasting triglycerides greater than 300 mg/dL - Fasting glucose greater than 126 mg/dL - History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g. vegetarians, very low fat diets, high protein diets) - Use of prescription of over-the-counter antiobesity medications or supplements during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity - Active cardiovascular disease - Use of any tobacco products in the past 6 months - Use of oral or IV antibiotics during the month preceding the study or during the study - Unwillingness to abstain from vitamin, mineral, and herbal supplements for two weeks prior to the start of the study - Known (self-reported) allergy or adverse reaction to blackberries or gelatin - Unable or unwilling to give informed consent or communicate with study staff - Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) - Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol |
結果
主な結果の測定
1. Change from baseline in 8-oxo-dG levels after 5 days [Day 5]
