Cardiac Arrhythmias in Dravet Syndrome
キーワード
概要
日付
最終確認済み: | 10/31/2017 |
最初に提出された: | 04/08/2015 |
提出された推定登録数: | 04/12/2015 |
最初の投稿: | 04/13/2015 |
最終更新が送信されました: | 09/04/2018 |
最終更新日: | 09/06/2018 |
実際の研究開始日: | 05/31/2015 |
一次完了予定日: | 08/28/2018 |
研究完了予定日: | 08/28/2018 |
状態または病気
段階
適格基準
研究の対象となる年齢 | 6 Years に 6 Years |
研究に適格な性別 | All |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Criteria: Cases must meet all of the following criteria: 1. DS with a known pathogenic SCN1A mutation 2. seizure frequency ≥ 1/week (all seizure types expect for absences or myoclonias) 3. no self-harm 4. age ≥ 6 years Each case will be matched to two historical controls (age +/- 5 years). Controls will meet the following criteria: 1. definite diagnosis of epilepsy 2. no clinical suspicion of DS 3. at least two seizures recorded (all seizure types expect for absences or myoclonias) during video-EEG registration. 4. age ≥ 6 years |
結果
主な結果の測定
1. Ictal asystole (sinus arrest ≥ 3 s) or ictal bradycardia (< 2nd heart rate percentile for age) [We will record heart rate patterns during seizures with miniaturized wearable EKG-monitors for 2 periods of 10 days]
二次的な結果の測定
1. Ictal QT lengthening or shortening [We will record heart rate patterns during seizures with miniaturized wearable EKG-monitors for 2 periods of 10 days]