Effects of Berries and Berry Fractions on Metabolic Diseases
キーワード
概要
説明
The aim of the project was to investigate whether it is possible to reduce the risk of metabolic diseases with supplementing the diet with sea buckthorn berries (Hippophaë rhamnoides), their bioactive fractions, and bilberries (Vaccinium myrtillus). The study design was a randomized cross-over clinical trial. The participants were slightly and moderately overweight female subjects. In total, 110 female volunteers were recruited, and they followed four different berry diets (bilberry, sea buckthorn, sea buckthorn phenolic extract and sea buckthorn oil) in a randomized order for 33-35 days. Each intervention was followed by a wash-out period of 30-39 days. Blood samples were drawn and physical measurements were performed after each period. Eighty volunteers completed the study. Different markers of lipid and carbohydrate metabolism and inflammation were measured form the blood samples.
日付
| 最終確認済み: | 04/30/2013 |
| 最初に提出された: | 04/28/2013 |
| 提出された推定登録数: | 05/19/2013 |
| 最初の投稿: | 05/21/2013 |
| 最終更新が送信されました: | 05/19/2013 |
| 最終更新日: | 05/21/2013 |
| 実際の研究開始日: | 05/31/2008 |
| 一次完了予定日: | 05/31/2009 |
| 研究完了予定日: | 07/31/2009 |
状態または病気
介入/治療
Dietary Supplement: bilberry
Dietary Supplement: sea buckthorn berry
Dietary Supplement: sea buckthorn phenolic extract
Dietary Supplement: sea buckthorn oil
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: bilberry | Dietary Supplement: bilberry Frozen bilberries, 100 g/d |
| Experimental: sea buckthorn berry | Dietary Supplement: sea buckthorn berry Dried sea buckthorn berries, 20 g/d |
| Experimental: sea buckthorn phenolic extract | Dietary Supplement: sea buckthorn phenolic extract Ethanol-water extract from sea buckthorn berries, combined with maltodextrin, 14.6 g/d (7.3 g sea buckthorn extract + 7.3 g maltodextrin) |
| Experimental: sea buckthorn oil | Dietary Supplement: sea buckthorn oil Sea buckthorn oil, 4 g (8 capsules)/d |
適格基準
| 研究の対象となる年齢 | 30 Years に 30 Years |
| 研究に適格な性別 | Female |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - BMI 26-34 - total cholesterol 4.5-8 mmol/l - LDL chol >2.5 mmol/l - triglycerides <4 mmol/l - glucose <6 mmol/l - insulin <25 mU/l - blood pressure <160/99 mm Hg - hemoglobin >120 g/l - thyroid-stimulating hormone 0.3-4.2 mU/l - ALAT <60 U/l - creatinine <115 umol/l Exclusion Criteria: - pregnancy - menopause, - regular smoking - previously diagnosed diabetes (other than gestational) - thyroid, renal, hematological, or hepatic dysfunction - previous myocardial infarction - cardiovascular medication - treatment with regular medication other than allergy medication or joint lubricates - on-going inflammatory disease |
結果
主な結果の測定
1. Serum Alanine aminotransferase (ALAT) [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
二次的な結果の測定
1. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerols [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
2. Plasma glucose [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
3. Serum gamma-glutamyl transpeptidase [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
4. Serum high-sensitivity C-reactive protein [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
5. Serum insulin [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
6. Serum soluble intercellular adhesion molecule [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
7. Serum tumor necrosis factor -alpha [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
8. Body mass index [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
9. Serum soluble vascular cell adhesion molecule [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
10. Serum adiponectin [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
11. Serum interleukine-6 [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
12. Weight [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
13. Waist circumference [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
14. Body composition [Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)]
その他の成果対策
1. Subclasses of serum lipoproteins, serum fatty acids and lipid classes of serum [Change from beginning to end of each berry treatment (duration of treatments average 33-35 days)]
