Inflammation, Polyphenols, and Genetics
キーワード
概要
説明
A high-fat, high-calorie challenge meal is administered to induce an inflammatory response in overweight and obese adult males. Serum levels of CRP, TNF-alpha, and IL-6 are measured prior to the challenge meal and at various times (1,2,4,8, and 12 hours) after the challenge meal. The challenge meal is given once without intervention and once after 5 daily doses of concentrated black-raspberry powder mixed in water.
日付
| 最終確認済み: | 08/31/2016 |
| 最初に提出された: | 03/28/2012 |
| 提出された推定登録数: | 03/28/2012 |
| 最初の投稿: | 04/01/2012 |
| 最終更新が送信されました: | 09/25/2016 |
| 最終更新日: | 09/26/2016 |
| 最初に提出された結果の日付: | 09/24/2015 |
| 最初に提出されたQC結果の日付: | 02/16/2016 |
| 最初に投稿された結果の日付: | 03/14/2016 |
| 実際の研究開始日: | 02/29/2012 |
| 一次完了予定日: | 04/30/2012 |
| 研究完了予定日: | 04/30/2012 |
状態または病気
介入/治療
Dietary Supplement: Blackraspberry Slurry
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Blackraspberry slurry, washout, water Blackraspberry slurry daily x 5 days, 2 day washout, 8 oz. water daily x 5 days | |
| Experimental: Water, washout, Blackraspberry slurry 8 oz. water daily x 5 days, 2 day washout, Blackraspberry slurry daily x 5 days |
適格基準
| 研究の対象となる年齢 | 55 Years に 55 Years |
| 研究に適格な性別 | Male |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - adult males over 55 years of age - overweight or obese Exclusion Criteria: - history of adverse reaction to berries or berry products - history of adverse reaction to high-fat, high-calorie challenge meal - significant liver or renal insufficiency - significant cognitive impairment |
結果
主な結果の測定
1. Serum IL-6 [acute (0-12 hours) after inflammation-causing challenge meal]
