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Orange Juice Consumption and Glucose Metabolism and Antioxidative Status

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University of Hohenheim

キーワード

概要

Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.

説明

Duration of the study is 3x three weeks including one wash-out week each followed by two weeks of juice/SSB consumption under free living conditions.

During wash-out weeks consumption of orange juice or citrus fruits is restricted.

During intervention weeks, participants are asked to eat three regular meals per day without snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice consumption between meals and (iii) SSB consumption between meals. Daily energy intake with orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB, juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each intervention phase insulin sensitivity and antioxidative status are assessed.

日付

最終確認済み: 03/31/2017
最初に提出された: 11/01/2016
提出された推定登録数: 11/21/2016
最初の投稿: 11/27/2016
最終更新が送信されました: 04/21/2017
最終更新日: 04/24/2017
実際の研究開始日: 03/31/2016
一次完了予定日: 11/30/2016
研究完了予定日: 11/30/2016

状態または病気

Healthy

介入/治療

Dietary Supplement: Orange juice with meals

Dietary Supplement: Orange juice between meals

Dietary Supplement: Sugar sweetened beverage between meals

段階

-

アームグループ

介入/治療
Experimental: Orange juice with meals
Effect of orange juice consumption with three meals per day (without snacking) on glucose metabolism and antioxidative status
Dietary Supplement: Orange juice with meals
orange juice (20% of energy requirement/day)
Experimental: Orange juice between meals
Effect of orange juice consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status
Dietary Supplement: Orange juice between meals
orange juice (20% of energy requirement/day)
Experimental: Sugar sweetened beverage between meals
Effect of sugar sweetened beverage consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status
Dietary Supplement: Sugar sweetened beverage between meals
Sugar sweetened beverage (20% of energy requirement/day)

適格基準

研究の対象となる年齢 20 Years に 20 Years
研究に適格な性別All
健康なボランティアを受け入れるはい
基準

Inclusion Criteria:

- healthy

Exclusion Criteria:

- regular use of medication,

- smoking,

- chronic disease,

- vegan/vegetarian diet,

- fructose intolerance,

- irregular eating behaviour (less then 3 meals/day)

結果

主な結果の測定

1. changes in daylong glycaemia between pre and post intervention periods [two weeks]

measured via continuous glucose monitoring [mg/dL]

二次的な結果の測定

1. changes in uric acid between pre and post intervention periods [two weeks]

measured via uric acid serum levels [mg/dL]

2. changes in insulin sensitivity between pre and post intervention periods [two weeks]

measured via "Matsuda-Index" from oral glucose tolerance test data

3. changes in antioxidative status between pre and post intervention periods [two weeks]

measured via vitamin c blood levels [mg/L]

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