The Association Between Areca-nut Chewing Habit and Metabolic Syndrome
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状態
スポンサー
Taichung Veterans General Hospital
臨床試験: NCT02175524
BioSeek: NCT02175524
キーワード
概要
The purpose of this study is going to determine the odds ratio of metabolic syndrome (MS), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients. The current study was designed as a case-control study. Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing are defined as case group. Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing are defined as control group. The participants' age, blood pressures, and smoking habits will be recorded. Body weight, height, waist, and hip circumferences will be measured. Fasting venous blood samples will be obtained to determine hematological parameters [i.e., serum creatinine, total cholesterol, triacylglycerol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, and inflammatory markers (C-reactive protein, tumor necrosis factor-alpha, and interleukin-6)]. Logistic regression analyses are going to perform to examine the relationship between areca nut chewing and MS in this population. If we can make sure the relationship between areca nut chewing and MS, the clinicians and nutritionists can teach people to quit areca nut chewing in order to avoid the possibility of developing metabolic syndrome and cardiovascular disease.
日付
最終確認済み: | 05/31/2014 |
最初に提出された: | 06/23/2014 |
提出された推定登録数: | 06/23/2014 |
最初の投稿: | 06/25/2014 |
最終更新が送信されました: | 06/23/2014 |
最終更新日: | 06/25/2014 |
実際の研究開始日: | 03/31/2014 |
一次完了予定日: | 11/30/2017 |
状態または病気
Oral and Esophageal Cancer
Metabolic Syndrome.
段階
-
アームグループ
腕 | 介入/治療 |
---|---|
Case Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing. | |
Control Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing. |
適格基準
研究の対象となる年齢 | 20 Years に 20 Years |
研究に適格な性別 | All |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - Patients proved to be oral and esophageal cancer will be recruited. Exclusion Criteria: - Subjects with diabetes mellitus, liver, renal diseases, or undergoing statin therapy. - Taking antioxidant vitamins supplements. |
結果
主な結果の測定
1. Metabolic syndrome [Up to 1 week]
Measure blood pressure, blood lipid profiles, fasting glucose, and waist circumferences.
二次的な結果の測定
1. Antioxidant activity [Up to 1 week]
Antioxidant ability measurements: lipid peroxidation markers (MDA), antioxidant enzymes activities (catalase, glutathione peroxidase, and superoxide dismutase).
2. Inflammatory status [Up to 1 week]
Measure inflammatory markers: C-reactive protein, Interleukin-6, and tumor necrosis factor-alpha.