Thiamin Deficiency in Obese Thai Children
キーワード
概要
説明
This study is a cross-sectional study. The objectives of the study are to determine the prevalence of thiamin deficiency in obese Thai children and to assess the associations of dietary factors and thiamin deficiency.
日付
| 最終確認済み: | 08/31/2018 |
| 最初に提出された: | 05/17/2015 |
| 提出された推定登録数: | 06/02/2015 |
| 最初の投稿: | 06/07/2015 |
| 最終更新が送信されました: | 09/27/2018 |
| 最終更新日: | 10/01/2018 |
| 実際の研究開始日: | 07/31/2015 |
| 一次完了予定日: | 06/30/2018 |
| 研究完了予定日: | 07/31/2018 |
状態または病気
介入/治療
Drug: Thiamine 1
Other: Non-thiamine
Drug: Thiamine 2
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Thiamine 1 presence of severe symptoms and signs of thiamine deficiency: heart failure, convulsion, coma, loss of ankle and knee jerks with muscular wasting and paralysis (typically symmetrical foot- and wrist-drop) | Drug: Thiamine 1 If severe symptoms and signs of thiamine deficiency are present, thiamine is prescribed.
Intervention 1 : severe symptom (heart failure, convulsion, or coma) : 50 mg thiamin administered very slowly intravenously, followed by a daily intramuscular dose of 10 mg for a week, and finally followed by 3-5 mg of thiamine per day orally for at least 6 weeks |
| Other: Non-thiamine no symptoms and signs of thiamine deficiency | Other: Non-thiamine no symptoms and signs of thiamine deficiency |
| Experimental: Thiamine 2 presence of mild symptoms and signs of thiamine deficiency; peripheral neuropathy alone (paraesthesia of hands and feet) | Drug: Thiamine 2 If symptoms and signs of thiamine deficiency are present, thiamine is prescribed.
If mild symptom : a daily oral dose of 10 mg thiamin during the first week, followed by 3-5 mg of thiamin per day orally for at least 6 weeks |
適格基準
| 研究の対象となる年齢 | 7 Years に 7 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - obese : weight for height > median + 3 standard deviations - simple obesity Exclusion Criteria: - pathological obesity - chronic diseases e.g. cerebral palsy, metabolic disease, etc. - diseases of red blood cells - on medication e.g. steroid, multivitamins, thiamine-containing vitamins, diuretic drugs - hemodialysis or peritoneal dialysis - bariatric surgery |
結果
主な結果の測定
1. abnormal thiamin pyrophosphate effect [7 days]
二次的な結果の測定
1. consumption of thiaminase-containing foods and thiamin antagonist-containing foods [7 days]
