Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma
キーワード
概要
説明
Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.
日付
最終確認済み: | 07/31/2018 |
最初に提出された: | 08/03/2018 |
提出された推定登録数: | 08/03/2018 |
最初の投稿: | 08/08/2018 |
最終更新が送信されました: | 08/07/2018 |
最終更新日: | 08/09/2018 |
実際の研究開始日: | 04/30/2016 |
一次完了予定日: | 04/30/2017 |
研究完了予定日: | 04/30/2017 |
状態または病気
段階
アームグループ
腕 | 介入/治療 |
---|---|
healthy individuals Orally and systemically healthy individuals who has no hypo-functional teeth, hyper-occlusion or occlusal trauma | |
periodontitis patients Systemically healthy individuals who has chronic periodontitis but no hypo-functional teeth, hyper-occlusion or occlusal trauma | |
healthy-occlusal trauma Orally and systemically healthy individuals who has occlusal trauma caused by bruxism | |
periodontitis-occlusal trauma Systemically healthy individuals who has both chronic periodontitis and occlusal trauma caused by bruxism |
適格基準
研究の対象となる年齢 | 29 Years に 29 Years |
研究に適格な性別 | All |
サンプリング方法 | Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - Systemical health - No drug use - No pregnancy or lactation For group 3 and 4; - Bruxism at least for 2 years - Occlusal trauma - Existence of at least 20 functioning teeth Exclusion Criteria: - Smoking - Pregnancy/lactation - Systemical disease - Drug use - Absence of at least 20 functioning teeth |
結果
主な結果の測定
1. Determination of certain bacterial species in subgingival dental plaque [A day after initial examination]
二次的な結果の測定
1. hypoxic changes in gingiva and serum [One day after initial examination]