Analgesic Effects of Gabapentin and Paracetamol
キーワード
概要
説明
Gabapentin is an anti-convulsion medication and has a high affinity for voltage-gated calcium channel throughout the brain, acts by inhibition of release of excitatory neurotransmitters. As a lipophilic substance, it shows linear pharmacokinetics and has oral bioavailability greater than 90%. Gabapentin is used in a variety of condition as a therapeutic measure involving diabetic neuropathy, post-herpetic neuralgia, in partial seizures, restless leg syndrome, post-menopausal hot flashes, anxiety, resistant mood disorders, essential tremors, and numerous other modalities. Gabapentin is a muscle relaxant and anti-spasmodic, its analgesic effect has also be identified for moderate to severe pain.
日付
| 最終確認済み: | 12/31/2019 |
| 最初に提出された: | 11/10/2018 |
| 提出された推定登録数: | 08/22/2019 |
| 最初の投稿: | 08/27/2019 |
| 最終更新が送信されました: | 01/21/2020 |
| 最終更新日: | 01/26/2020 |
| 実際の研究開始日: | 08/31/2019 |
| 一次完了予定日: | 01/06/2020 |
| 研究完了予定日: | 01/20/2020 |
状態または病気
介入/治療
Drug: Gabapentin 600 mg Tab
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Group A Gabapentin 600 mg Tab | |
| Active Comparator: Group B Paracetamol 1000 mg Tab |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | 1. Inclusion Criteria: 1. Patients between 18-60 years of age 2. Patients Undergoing hand surgery in the Department of Plastics and Reconstructive Surgery, Dr. Ruth KM Pfau Civil Hospital Karachi, Dow University of Health Sciences 2. Exclusion criteria: 1. Pregnant women 2. Any patient presenting with the signs of: - Arrhythmia - Myocardial ischemia - Cognitive impairment - Psychiatric disorders - Drug abuse 3. Patients sensitive to any epileptic drug or taking any anti-epileptic drug 4. Having severe and multiple injuries. |
結果
主な結果の測定
1. Comparison of analgesic effects of Gabapentin and paracetamol in patients with hand injury [6 months]
