Avenanthramide and Saponin Bioavailability in Oat Bran
キーワード
概要
説明
Initially, the diet of the participants will be asked to restricted to avoid eating any polyphenols that might interfere with the employed analytical chemistry techniques. This period of diet restriction is the washout period. The list of foods to avoid are: oats, whole grains, fruits, vegetables, herbal supplements, ginger, coffee, tea, and chocolate.
After the washout period, a baseline urine and fecal sample will be collected from the participants, then a large portion of oat bran will be provided to the participants for consumption. The approximate portion size will be 100 g by dry weight. The participants will then provide urine samples during the designated time points. The time points for the urine collection are as follows:
1. st sample, ~ 30 min to 1 hour prior to oat consumption
2. nd sample: 0-2 hours after oat consumption
3. rd sample: 2-4 hours after oat consumption
4. th sample: 4-6 hours after oat consumption
5. th sample: 6-9 hours after oat consumption
6. th sample: 9-12 hours after oat consumption
7. th sample: 12-24 hours after oat consumption
8. th sample: 24-32 hours after oat consumption
9. th sample: 48 hours after oat consumption These samples will be analyzed in using HPLC and LC/MS.
日付
| 最終確認済み: | 03/31/2020 |
| 最初に提出された: | 04/01/2020 |
| 提出された推定登録数: | 04/02/2020 |
| 最初の投稿: | 04/05/2020 |
| 最終更新が送信されました: | 04/02/2020 |
| 最終更新日: | 04/05/2020 |
| 実際の研究開始日: | 01/14/2016 |
| 一次完了予定日: | 01/20/2016 |
| 研究完了予定日: | 01/20/2016 |
状態または病気
介入/治療
Dietary Supplement: Oat Bran Consumption
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Oat Bran Consumption Each subject consumed 120 g of oat bran (by dry weight) in a single dose, and samples (urine and fecal) were collected at different time points following the administration of oat bran. | Dietary Supplement: Oat Bran Consumption Oat bran (120 g), single dose. |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - BMI 18.5-25 - Have blood and urine biochemical markers in normal range - Have no known allergy to oat relate foods - Be not taking antibiotics for six months - Be not currently taking medication - Be nonsmoking - Have no alcoholic intoxication - Have no extensive exposure to industrial waste Exclusion Criteria: - Individuals with gout - Individuals with heart disease - Individuals with peripheral vascular diseases - Individuals with degenerative liver - Cancer patients - Patients with diabetes - Individuals with GI disorders - Individuals with endocrine disorders |
結果
主な結果の測定
1. Bioavailability of Avenanthramides and Saponins in Urine [0-2 hours post-dose]
2. Bioavailability of Avenanthramides and Saponins in Urine [2-4 hours post-dose]
3. Bioavailability of Avenanthramides and Saponins in Urine [4-6 hours post-dose]
4. Bioavailability of Avenanthramides and Saponins in Urine [6-9 hours post-dose]
5. Bioavailability of Avenanthramides and Saponins in Urine [9-12 hours post-dose]
6. Bioavailability of Avenanthramides and Saponins in Urine [12-24 hours post-dose]
7. Bioavailability of Avenanthramides and Saponins in Urine [24-32 hours post-dose]
8. Bioavailability of Avenanthramides and Saponins in Urine [32-48 hours post-dose]
