Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
キーワード
概要
日付
| 最終確認済み: | 04/30/2020 |
| 最初に提出された: | 07/05/2017 |
| 提出された推定登録数: | 08/27/2017 |
| 最初の投稿: | 08/28/2017 |
| 最終更新が送信されました: | 05/03/2020 |
| 最終更新日: | 05/04/2020 |
| 実際の研究開始日: | 08/31/2017 |
| 一次完了予定日: | 01/13/2019 |
| 研究完了予定日: | 11/30/2021 |
状態または病気
介入/治療
Dietary Supplement: Blueberry powder
Dietary Supplement: Blueberry placebo powder
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Blueberry powder | Dietary Supplement: Blueberry powder Subjects will consume blueberry powder during 8 weeks to test the possible effects of blueberries on gut microbiota composition and on metabolic syndrome parameters. |
| Placebo Comparator: Blueberry placebo powder | Dietary Supplement: Blueberry placebo powder Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder). |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Men and premenopause women in good health - Caucasians - At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men - At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L Exclusion Criteria: - Metabolic disorders (hypertension, diabetes, hypercholesterolemia) - Regular use of medication affecting study parameters - Use of natural health product in the last 3 months - Use of antibiotics in the last 3 months - Nicotine users - Allergy or intolerance for blueberries - Blueberry taste aversion - More than 2 alcohol drinks par day - Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) - Weight change of more than 5% in the last 3 months - Surgery in the last 3 months or planed during the study |
結果
主な結果の測定
1. Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
2. Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
二次的な結果の測定
1. Changes in gene expression in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
2. Changes in metabolites concentration in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
3. Changes in the gut microbiota composition in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
4. Changes in blood pressure of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
5. Changes in intestinal integrity of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
6. Changes in inflammation biomarkers of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
