Epigenetic Regulation of BDNF in Schizophrenia
キーワード
概要
説明
A total 160 subjects (80 subjects every year, including 40 healthy controls and 40 schizophrenia patients) will be recruited during a 2-year period. The first year, the baseline data of BDNF and Trk B DNA methylation, protein and mRNA levels in all subjects will be collected and the following 1 months data will also be collected in schizophrenia with antipsychotic drug treatments. The second year, the baseline data of BDNF and Trk B histone modification in all subjects will be collected.
日付
| 最終確認済み: | 08/31/2013 |
| 最初に提出された: | 11/24/2009 |
| 提出された推定登録数: | 11/26/2009 |
| 最初の投稿: | 11/29/2009 |
| 最終更新が送信されました: | 09/10/2013 |
| 最終更新日: | 09/11/2013 |
| 実際の研究開始日: | 11/30/2008 |
| 一次完了予定日: | 10/31/2010 |
| 研究完了予定日: | 10/31/2010 |
状態または病気
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Control Healthy subjects | |
| Schizophrenia Schizophrenic patients |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| サンプリング方法 | Non-Probability Sample |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - 1. The clinical screening and assessment in schizophrenic patients： 1. 40 schizophrenia patients will be recruited in psychiatric inpatients according to DSM-IV criteria (APA, 1994) by a structured interview (SCID). The assessment will be done by two senior psychiatrists. The intra-rater and inter-rater reliability will be done before this project started 2. age : 18-65 years old. 3. The patients had the ability to complete the written inform consent.。 4. The choice of antipsychotic drugs depended on the need of patients in natural treatment procedure. They included conventional drugs, eg.haloperidol 10-20 mg/day；SDA (serotonin dopamine antagonist) drug, eg. clozapine 100-400 mg/day or risperidone 3-6mg/day. The choice of the medication was according to the need of patients including previous responses and side effects. 5. PANSS (Positive and Negative Syndrome)(Kay, 1987,1988&1989) for positive, negative symptoms and severity. 6. Check body mass index (BMI): if BMI<24: normal; 24 7. Suicide behavior in tis study includes complete suicide and suicide attempt. Exclusion Criteria: 1. The patients had systemic diseases, including metabolic, heart, and liver diseases。 2. The patients had received any drugs before entering this protocol. 3. The patients were heavy smokers or dependent on alcohol. |
結果
主な結果の測定
1. BDNF and Trk B DNA methylation, protein and mRNA levels [Two years]
二次的な結果の測定
1. the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients [two years]
