Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome
キーワード
概要
説明
A variety of dietary interventions have been used in the management of CFS, yet no therapeutic modality demonstrated overall positive results in terms of effectiveness (Whiting et al. 2001). Previous studies have evaluated the effects of essential fatty acids, vitamins, minerals and/or enzymes, with findings do not support the use of a broad-spectrum nutritional supplement in treating CFS‐related symptoms (Brouwers et al. 2002). Considering the fact that patients with CFS have lower levels of high-energy compounds (e.g. phosphocreatine, adenosine triphosphate) (Block et al. 1998), effective dietary treatment of CFS should be focused on providing compounds that facilitates cellular bioenergetics. Besides other candidate agents, guanidinoacetic acid (GAA) could be of particular interest since it occurs naturally in the human body and acts as an immediate precursor of creatine (Wyss and Kaddurah-Daouk, 2000). Due to its low cost and high bioavailability (Baker 2009), if proven effective dietary GAA may be suitable for use in broad CFS population.
日付
| 最終確認済み: | 12/31/2016 |
| 最初に提出された: | 08/04/2014 |
| 提出された推定登録数: | 08/06/2014 |
| 最初の投稿: | 08/10/2014 |
| 最終更新が送信されました: | 01/29/2017 |
| 最終更新日: | 01/31/2017 |
| 実際の研究開始日: | 07/31/2014 |
| 一次完了予定日: | 05/31/2015 |
| 研究完了予定日: | 06/30/2015 |
状態または病気
介入/治療
Dietary Supplement: Guanidinoacetic acid
Other: Placebo
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Guanidinoacetic acid Supplementation with dietary guanidinoacetic acid | Dietary Supplement: Guanidinoacetic acid Dietary supplement |
| Placebo Comparator: Placebo Supplementation with cellulose | Other: Placebo Placebo |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Adults who fulfilled the 1994 CDC criteria for CFS - Older than 18 years of age will be candidates for inclusion in the study. Exclusion Criteria: - Psychiatric comorbidity - Use of any dietary supplement within 4-weeks prior to the study commencing - Pregnant |
結果
主な結果の測定
1. Change in the Multidimensional Fatigue Inventory (MFI) score [Baseline and afetr 3 months]
二次的な結果の測定
1. Pain in the locomotive apparatus [Baseline and after 3 months]
その他の成果対策
1. Health-related quality of life [Baseline and after 3 months]
2. Daily physical activity [Baseline and after 3 months]
3. Muscular strength [Baseline and after 3 months]
4. Serum creatine [Baseline and after 3 months]
5. Side-effects prevalence [During 3 months of intervention]
