Impact of Training Status on Bioavailability of Flavanones

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University of Glasgow

臨床試験: NCT02627547

BioSeek: nct02627547

キーワード

概要

Flavonoids are compounds that have been proven to have a beneficial effect on health, such as reducing the risk of developing cardiovascular disease and, in some cases, cancer. Citrus juices have a high flavonoid content. However, the absorption of flavonoids into the body is limited. This study will investigate whether being physically active improves the absorption of flavonoids.

Endurance trained athletes will be invited to participate. Following screening procedures (a. Health Screening Questionnaire; b. height and weight measurement for calculation of Body Mass Index; c. maximal oxygen consumption (VO2max) uptake test, eligible participants will undertake two experimental tests; one during a period of normal training, the other immediately following 1 week of detraining.

In the morning of the experimental trial participants will consume 500 mL of orange juice. Blood samples and urinary fractions will be collected prior (base line) to and for 24 hours after orange juice consumption. Participants will be asked to follow a special polyphenol-free diet and record weighed dietary intake for 2 days preceding each trial and during the day of the experimental trial.

The study aims to:

1. Determine the effects of training status of endurance athletes on bioavailability of flavanones in endurance trained individuals

2. Determine whether changes in bioavailability of flavanones are related to changes in biomarkers of inflammation, oxidative stress, plasma lipids and insulin sensitivity.

日付

最終確認済み:	11/30/2015
最初に提出された:	12/01/2015
提出された推定登録数:	12/07/2015
最初の投稿:	12/10/2015
最終更新が送信されました:	12/07/2015
最終更新日:	12/10/2015
実際の研究開始日:	08/31/2013
一次完了予定日:	07/31/2015
研究完了予定日:	07/31/2015

状態または病気

Healthy

介入/治療

Behavioral: Experimental tests

段階

アームグループ

腕	介入/治療
Experimental: Experimental tests 2 sets of experimental tests; once, during a period of normal training and repeated following one week of de-training	Behavioral: Experimental tests 5-10 hours of endurance training each week

適格基準

研究の対象となる年齢	18 Years に 18 Years
研究に適格な性別	Male
健康なボランティアを受け入れる	はい
基準	Inclusion Criteria: - trained regularly for at least 4 years and typically perform at least 5 hours of endurance training per week (distance runners, triathletes, cyclists) - healthy - normotensive - non-smokers - not taking any drug therapies - VO2 max >50 ml/kg body mass Exclusion Criteria: - history of gastrointestinal disease - vegetarian - unstable food habits - VO2 max < 50 ml/kg body mass

結果

主な結果の測定

1. • Plasma pharmacokinetics of naringenin, hesperetin, eriodictyol, isorhamnetin and phenolic acid metabolites [24 hours]

Change in plasma concentrations collected at base line (0 hours) and 0.5,1, 2, 3,4,5,6,7,8, and 24 hours after ingestion of orange juice

2. • Urinary excretion of naringenin, hesperetin, eriodictyol, isorhamnetin and phenolic acid metabolites [24 hours]

Change in concentrations in urinary fraction collected at base line (0 hours) and after ingestion of orange juice (0-5, 5-8, 8-10, 10-24 hours)

二次的な結果の測定

1. Maximal Oxygen Consumption [30 minutes]

Maximal Oxygen Consumption (ml/kg/min) measured in trained state by Douglas bag method

2. Body weight [7 days]

Difference in body weight in kilograms between trained and detrained states measured by TANITA scales (TBF-300, Cranlea, UK)

3. Body fatness [7 days]

Difference in percentage of body fat between trained and detrained states measured by bioelectrical impedance method (TBF-300, TANITA, Cranlea, UK)

4. Dietary Intake [7 days]

Difference in energy/macronutrient intake between trained and detrained states measured from 7 day weighted food records

Impact of Training Status on Bioavailability of Flavanones

キーワード

polyphenol

悪性腫瘍

inflammation

インスリン抵抗性

flavanone

flavonoid

概要

日付

状態または病気

介入/治療

段階

アームグループ

適格基準

結果

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