Intervention With Legume Kernel Fibre in Healthy Subjects
キーワード
概要
説明
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower serum cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of legume kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
Seventy-eight healthy volunteers were enrolled. Seventy-six subjects (mean age of 24 years, 55 women and 21 men) completed the double-blind, randomized crossover trial. After two weeks run-in period, half of the volunteers consumed 25 g of legume fibres (Boregine, TypTop or Soy fibre) every day, and the other half received a reference fibre product (citrus fibre, Herbacel AQ Plus) for a period of two weeks. After two weeks wash-out the intervention changed between the groups.
At the end of each period a quantitative stool and urine collection took place and fasting blood samples were drawn.
日付
最終確認済み: | 11/30/2009 |
最初に提出された: | 12/16/2009 |
提出された推定登録数: | 12/17/2009 |
最初の投稿: | 12/20/2009 |
最終更新が送信されました: | 11/04/2012 |
最終更新日: | 11/05/2012 |
実際の研究開始日: | 06/30/2007 |
一次完了予定日: | 11/30/2007 |
研究完了予定日: | 11/30/2007 |
状態または病気
介入/治療
Dietary Supplement: pure fibre-product
Dietary Supplement: reference fibre
段階
アームグループ
腕 | 介入/治療 |
---|---|
Experimental: TypTop Lupinus albus Typ Top (lupin kernel fibre, dietary fibre content: 83%) | |
Experimental: Soy fibre Glycine max Hefeng (soy fibre; dietary fibre content: 77%) | |
Experimental: Boregine Lupinus angustifolius Boregine (lupin kernel fibre, dietary fibre content: 87%) |
適格基準
研究の対象となる年齢 | 20 Years に 20 Years |
研究に適格な性別 | All |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - age 20-45 years - healthy subjects Exclusion Criteria: - intake of pharmaceuticals and nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic diseases |
結果
主な結果の測定
1. Changes of serum lipids (cholesterol metabolism) [after 2, 4 and 8 weeks]
二次的な結果の測定
1. Changes of general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion [after 2, 4 and 8 weeks]