Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
キーワード
概要
説明
Elderly patients with parkinsonian syndrome and healthy age-matched controls are enrolled in this study. The subjects all undergo a brain MRI exam. Controls are selected to match the age distribution of patients.
Clinical evaluation The day of the brain MRI examination, all patients undergo a neurological and neuropsychological evaluation. Diagnoses are established by a neurologist experienced with parkinsonian syndromes according to established guidelines: the UK Parkinson's Disease Society Brain Bank criteria for idiopathic PD, the National Institute of Neurological Disorders and Stroke and the Society for Progressive Supranuclear Palsy criteria for progressive supranuclear palsy, Lang's criteria for corticobasal dementia, Gilman's criteria for multiple system atrophy and Zijlmans's criteria for vascular parkinsonism.
Impairment of the motor function related to parkinsonian syndrome is assessed using the Hoehn and Yahr scale (range 0-5), the Schwab and England Activities of Daily Living scale (range 0-100%), the Unified Parkinson's Disease Rating Scale (UPDRS, range 0-199) and the Short Motor Disability scale (range 0-17).
Cognitive impairment is assessed using the Mini Mental Sate Examination (MMSE) score (range 0-30), the Grober and Buschke verbal-learning test (range 0-16), a semantic-processing task (LEXIS test, range 0-64), the forward/backward Digit span task (range 0-17) of the third Wechsler Adult Intelligence Scale and the Rey-Osterrieth Complex-Figure (ROCF) test (range 0-36) to assess visuospatial abilities, attention, executive function and working memory.
The Mattis Dementia-Rating scale (range 0-144) and the Beck Depression Inventory (range 0-63) are performed to look for depression. The Educational Attainment and the National Institute of Health Stroke Score (NIHSS) (range 0-42) are also recorded.
MRI acquisition and processing. All patients undergo a brain MRI on a 3-Tesla scanner including 3D triple echo gradient echo acquisition to generate susceptibility weighted images, T1-weighted magnetisation-prepared rapid 3D gradient-echo (MPRAGE) and diffusion tensor imaging acquisition.
Susceptibility weighted imaging raw data are preprocessed to obtain magnitude and phase images for each echo time. Quantitative susceptibility maps are then generated using SPM8 software (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK; http://www.fil.ion.ucl.ac.uk/spm/, Matlab 2014a, The MathWorks, Natick, MA, USA).
日付
| 最終確認済み: | 02/28/2017 |
| 最初に提出された: | 05/06/2015 |
| 提出された推定登録数: | 05/11/2015 |
| 最初の投稿: | 05/14/2015 |
| 最終更新が送信されました: | 03/29/2017 |
| 最終更新日: | 03/30/2017 |
| 実際の研究開始日: | 11/30/2012 |
| 一次完了予定日: | 11/30/2016 |
| 研究完了予定日: | 11/30/2016 |
状態または病気
介入/治療
Other: MRI exam of the brain
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Other: Parkinson's disease MRI exam of the brain | |
| Other: Multiple System Atrophy MRI exam of the brain | |
| Other: Progressive Supranuclear Palsy MRI exam of the brain | |
| Other: Vascular parkinsonism MRI exam of the brain | |
| Other: Healthy volunteers MRI exam of the brain |
適格基準
| 研究の対象となる年齢 | 70 Years に 70 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - For Both patients and healthy volunteers : - Age limits ≥ 70 et ≤ 90 years - Subject able to understand the nature, the aim and the methodology of the study. - Collection of the infomed consent - Affiliation or recipient with the mode of social security. - For the patients : Parkinsonian Syndrome began after 65 years defined as Parkinson's disease Multiple System Atrophy (AMS), Progressive Supranuclear Palsy, Vascular Parkinson - For the healthy volunteers : The healthy volunteers will be selected according to the age and the of the study's patients. Exclusion Criteria: - For Both patients and healthy volunteers : - Person with majority age protected by the law (supervision or trusteeship). - Loss of liberty per court order or administative - Subject presenting contraindications in MRI (valve of ventricular diversion, Ferromagnetic foreign bodies, pace-maker, Implantable defibrillator (ICD), Cochlear hearing implant, Claustrophobia, ….) - Antecedent of serious cranial trauma (according to classification) of ischeamic stroke ou intracranial hematoma. - For the patients : •Patient treated by neuroleptics - For the healthy volunteers : - Antecedent of neurological desease - Antecedent of psychiatric trouble de trouble psychiatrique (Except anxio-depressive disorder) - In period of exclusion relative to another protocol or which the annual amount of the allowances maximum of 4500 € was reached. |
結果
主な結果の測定
1. Quantitative susceptibility mapping [1 month]
二次的な結果の測定
1. Diffusion tensor imaging [1 month]
