Phase II Pazopanib Study in Advanced Dermatofibrosarcomas
キーワード
概要
説明
Dermatofibrosarcoma protuberance (DFSP) is a rare soft tissue sarcoma of intermediate malignant potential. Treatment relies on a wide local excision with negative margin and with frequent need of reconstructive surgery. A translocation between chromosomes 17 and 22 that places the platelet-derived growth factor-B (PDGFB) under the control of the collagen 1A1 promoter is present in > 90 % of the cases leading to an up regulation of PDGF-β expression and activation of the tyrosinase kinase PDGFRβ. Imatinib mesylate has been approved in unresectable and metastatic DFSP due to its activity on PDGFR. This study will evaluate the benefit of pazopanib, a multikinase inhibitor in advanced DFSP. Administration of pazopanib per os 800mg/ qd during 6 months until stable response according to primary endpoint , and for a period of study not exceeding one year.In case of progression evaluated according to the primary endpoint after a period of treatment superior to one month, or in the absence of response at 3 months, the patient will be withdrawn from study, in order to get alternative therapeutics. These patients will be considered as failures for analysis. After a 6-month treatment period, and reaching a stable response, treatment continuation decision will be based on the operability of patients.
Administration of pazopanib per os 800mg/ qd during 6 months until stable response according to primary endpoint, with 3 monthly successive examinations, and for a period of study not exceeding 18 months.In case of progression evaluated according to the primary endpoint after a period of treatment superior to one month, or in the absence of response at 3 months, the patient will be withdrawn from study, in order to get alternative therapeutics. These patients will be considered as failures for analysis. After a 6-month treatment period, and reaching a stable response, treatment continuation decision will be based on the operability of patients Statistical analysis : The trial has been planned using a one-stage design (Fleming TR. Et al) Analysis of the main endpoint will rely on a one-sided binomial test comparing the observed response rate to the expected response rate under the null hypothesis . The type I error rate is fixed at 0.025.For the main endpoint, a point estimate and a two-sided 90% confidence interval will be presented, which will be consistent with the one-sided test at a 0.025 level. For secondary endpoints, point estimates and 95% confidence intervals will be presented.We intend to estimate the probability of tumour size reduction of at least 30%. The sample size was calculated by FLEMMING method : Ho will be defined by a RR ≤20% (decrease in tumour size of at least 30%) , H1 , response rate, 26 patients must be included in order to demonstrate an efficacy as defined by a RR≥50%, with a 90% power and alfa 2.5% one side.
日付
| 最終確認済み: | 05/31/2016 |
| 最初に提出された: | 01/27/2010 |
| 提出された推定登録数: | 01/27/2010 |
| 最初の投稿: | 01/31/2010 |
| 最終更新が送信されました: | 06/29/2016 |
| 最終更新日: | 06/30/2016 |
| 実際の研究開始日: | 06/30/2010 |
| 一次完了予定日: | 03/31/2014 |
| 研究完了予定日: | 03/31/2014 |
状態または病気
介入/治療
Drug: 1:Pazopanib
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: 1:Pazopanib Pazopanib 800mg/j | Drug: 1:Pazopanib Administration of pazopanib per os 800mg/ qd during 6 months until stable response according to primary endpoint, with 3 monthly successive examinations, and for a period of study not exceeding 18 months. |
適格基準
| 研究の対象となる年齢 | 20 Years に 20 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Primitive unresectable DFSP, locally advanced (potentially mutilating surgery), or in relapse or transformed. - Histologic confirmation of the Darier-FERRAND tumour (transformed types will be accepted provided a previous caryotype confirming the translocation (17,22) - Age > or equal to 20 years - Signed informed consent - Appropriate contraception - No evolutive tumoural disease except baso-cellular carcinoma - Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1. Exclusion Criteria: - Patient refusal to participate - Age < 20 years - Pregnant or lactating women - Other evolutive tumour disease except baso-cellular carcinoma - Haematologic abnormalities:Hemoglobin < 9g/dl, PNN < - 1500/mm3, Platelets <100000/mm3 - AST and ALT > 2N - Bilirubin > 1.5N - Creatinin > 1.5mg/dL or creatinin clearance <30ml/mn - Proteinuria >1g/24h - Serum albumin< 2.5g/dL - Hepatitis B, C and/or HIV known Infection - Treatment interfering with pazopanib - Major surgical procedure, open biopsy, or significant traumatic injury within 4 weeks prior to beginning therapy, or anticipation of the need for a major surgical procedure during the course of the study. - Clinically significant gastrointestinal abnormalities including, but not limited to:Malabsorption syndromeDisease significantly affecting gastrointestinal function or major resection of the stomach or small bowel that could affect the absorption of study drug.Active peptic ulcer diseaseInflammatory bowel diseaseUlcerative colitis, erosive esophagitis or gastritis, infectious or inflammatory bowel disease, diverticulitis or other gastrointestinal condition increasing the risk of perforation.History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to beginning study treatment· Presence of active or uncontrolled infection. - Evidence of active bleeding or bleeding diathesis. - History of any one or more of the following cardiovascular conditions within the past 6 months:Coronary/peripheral artery bypass graft, cardiac angioplasty or stenting.Myocardial infarction.Severe/unstable angina pectoris.Symptomatic peripheral vascular disease pulmonary embolism, thromboembolic event, cerebrovascular accident or transient ischemic attack.Class III or IV congestive heart failure, as defined by the New York Heart Association - Cardiovascular disease with NYHA > II - Poorly controlled hypertension (defined as a systolic blood pressure (SBP) of ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg. - Following abnormalities on ECG : Q wave, ischemia, QTc > 450 msec, atrioventricular block 2 or 3, atrial fibrillation - Therapeutic anticoagulation treatment. - Chronic daily treatment with aspirin (≥ 100 mg/day) or non-steroidal anti-inflammatory agents known to inhibit platelet function. Treatment with dipyridamole, ticlopidine, clopidogrel and/or cilostazol is also not allowed.. Concurrent treatment with an investigational agent or participation in another clinical trial. - Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib. - Taken by the order treatment anti cancerous concomitants within 4 weeks previous inclusion - Radiotherapy on the hurt within 3 months previous inclusion |
結果
主な結果の測定
1. Decrease of at least 30% of the biggest diameter measured clinically at 6 months preceded by clinical response [at 3 months]
二次的な結果の測定
1. For measure of tumour volume : Measure of radiologic response (" MULTIBARETTE " MDCT scanner) using RECIST criteria and OMS (WHO) [at 3 months]
2. For measure of tumour volume : Measure of the volume of the tumour (" MULTIBARETTE " MDCT scanner) in each centre [at 3 months]
3. For measure of tumour volume : Research of translocation COL1A1-PDGFB by FISH (paraffin) and caryotype on fresh tissue (centralisation in F PEDEUTOUR laboratory, Nice) [at 3 months]
4. Prognostic factors of tumoral response : Semi-quantitative measure of apoptosis on surgical piece and of senescence [at inclusion, M1, M3 and M6]
5. Expression of the phosphorylated form of the receptors of PDGFB and VEGF and of the MAPK. [at inclusion, M1, M3 and M6]
6. Prognostic factors of tumoral response :Clinical and biologic safety Common Terminology Criteria forAdverse Events v3.0 (CTCAE) [at every visit except M0]
7. Prognostic factors of tumoral response :Evaluation of QOL, EORTC QLQ-C30 [M0, M3, M6, M9, M12, M15 and M18]
