Renal Function During Pediatric Anesthesia
キーワード
概要
説明
Prior studies by the investigators research group have shown water and sodium retention in experimental animals undergoing sevoflurane anesthesia. Preliminary data suggest that this is not as obvious with propofol anesthesia. The investigators aim to study if this difference is present in children.
Subjects are collected from ordinary routine operations of hypospadia. By routine, all boys undergoing this surgery get a sacral blockade and a urine catheter. The children are randomized to either sevoflurane or propofol anesthesia. Before or immediately after induction of anesthesia baseline blood samples are collected for analysis of sodium, potassium, creatinine, osmolality, angiotensin II, arginine-vasopressin and aldosterone. Perioperative fluids are started, a balanced glucose infusion with 132mmol sodium content, covering basal fluid need + 20%. This infusion is continued until the end of the protocol at the ward. At the induction of anesthesia the investigators start measuring urine output every 20th minute. The same blood samples as above are collected again during mid-operation. At the end of anesthesia the investigators collect all the urine and send a sample for urine analysis of sodium, potassium, osmolality and creatinine.
In the postoperative ward the investigators again start collecting urine every 20 minutes for 120 minutes. All urine after 120 minutes are collected, and a sample sent for analysis. After 60 minutes at the postoperative ward, blood samples are again collected for analysis.
In the childrens ward the protocol for the postoperative ward is repeated, with urine collection and sample, as well as blood samples. After 120 minutes the protocol ends.
日付
| 最終確認済み: | 09/30/2015 |
| 最初に提出された: | 10/04/2015 |
| 提出された推定登録数: | 10/05/2015 |
| 最初の投稿: | 10/07/2015 |
| 最終更新が送信されました: | 10/21/2015 |
| 最終更新日: | 10/22/2015 |
| 実際の研究開始日: | 09/30/2015 |
| 一次完了予定日: | 05/31/2016 |
| 研究完了予定日: | 11/30/2016 |
状態または病気
介入/治療
Drug: sevoflurane
Drug: Propofol
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Active Comparator: Propofol Continuous infusion during surgery. Individual dosage. | Drug: Propofol anesthetic agent |
| Active Comparator: sevoflurane Inhalational anesthetic during surgery. Individual dosage | Drug: sevoflurane anesthetic agent |
適格基準
| 研究の対象となる年齢 | 1 Year に 1 Year |
| 研究に適格な性別 | Male |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Eligible for hypospadia surgery. Exclusion Criteria: - American Association of Anesthesiology class above 2 - Weight above 50 kg or below 10 kg - Hypersensitivity towards the anesthetic agents (difficult peanut or soy allergy) - Inability for parent to understand study information |
結果
主な結果の測定
1. urine output during anesthesia [2 hours]
二次的な結果の測定
1. urine output postoperatively [4 hours]
2. sodium excretion postoperatively [4 hours]
3. Changes in aldosterone, angiotensin II, arginine-vasopressin during surgery [2 hours]
4. Changes in aldosterone, angiotensin II, arginine-vasopressin postoperatively [4 hours]
5. Sodium excretion during anesthesia [2 hours]
