Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients
キーワード
概要
説明
Methods:
In Assaf Harofe medical center over 50 adolescents (mainly girls) aged 10-18 years are treated annually for eating disorders by a multidisciplinary team. Their nutritional and medical condition is assessed also by blood analysis routinely. The investigators are planning to check thiamine status in eating disorders female patients in different stages of treatment, comparing them with age and sex matched controls that do not have eating disorders problems. The control group will be recruited from patient treated in the outpatient day hospital and have blood tested anyhow that don't suffer from eating, metabolic, nutritional or gastrointestinal disorders.
The researchers will look for correlation between different types of eating disorders, nutritional state, treatment progress and levels of vitamin B1.
Thiamin will be determined in whole blood using High-Performance Liquid Chromatography (HPLC) that is superior to the previous method as described above, determining thiamin diphosphate; the physiologically active form of vitamin B1 accurately.
Sample size: A previous study on thiamine concentration in 50 healthy French volunteers found a standard deviation (SD) of 15 nmol/l (7). 17 patients in each group were required in order to detect a 15 nmol/l difference in mean thiamine levels with a power of 80% and Alfa of 0.05. In order to overcome a possibly higher SD and to allow for subgroup analysis , we decided to recruit 30 patients for each group.
日付
最終確認済み: | 04/30/2020 |
最初に提出された: | 06/05/2013 |
提出された推定登録数: | 06/12/2014 |
最初の投稿: | 06/15/2014 |
最終更新が送信されました: | 05/23/2020 |
最終更新日: | 05/26/2020 |
実際の研究開始日: | 02/28/2013 |
一次完了予定日: | 11/30/2015 |
研究完了予定日: | 12/31/2015 |
状態または病気
段階
アームグループ
腕 | 介入/治療 |
---|---|
B1 blood levels |
適格基準
研究の対象となる年齢 | 12 Years に 12 Years |
研究に適格な性別 | Female |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - Adolescent girls aged 12-18 Exclusion Criteria: - Girls suffering from metabolic - Nutritional or gastrointestinal disorders |
結果
主な結果の測定
1. establishing B1 levels [one year]