Journal of Ethnopharmacology 1991-Jan
Antitumor activity of quassinoids from Hannoa klaineana.
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概要
Of the five quassinoids isolated from the root bark of Hannoa klaineana, only 15-desacetylundulatone was found active against P388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma. Undulatone and especially 15-O-beta-D-glucopyranosyl-21-hydroxy-glaucarubolone were found to be more toxic while 6 alpha-tigloyloxy-glaucarubol and 21-hydroxyglaucarubolone were found inactive. Structure-activity relationships are discussed.
