[Studies on bioactive constituents of whole herbs of Vernonia cinerea].
キーワード
概要
OBJECTIVE
To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model.
METHODS
The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.
RESULTS
Four compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated.
CONCLUSIONS
Compounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity.
