Biomedica biochimica acta 1984
The effect of phenylhydrazine on protein breakdown in rabbit reticulocytes.
登録ユーザーのみが記事を翻訳できます
ログインサインアップ
リンクがクリップボードに保存されます
キーワード
概要
In contrast to reticulocytes produced by bleeding reticulocytes produced by injections of phenylhydrazine exhibit a sizeable Antimycin A- and a large salicylhydroxamic acid (SHAM)-resistant proteolysis. In their cytosol there exist both ATP-independent and ATP-dependent protease systems. The substrate of proteolysis are denatured and aggregated proteins arising from reactions of phenylhydrazine with cell constituents. In phenylhydrazine-induced reticulocytes there is an overlap between the basic biological process of maturation-dependent proteolysis of mitochondria and the breakdown of denatured and aggregated "abnormal" proteins.