Steroidal saponins from Raphia vinifera and their Cytotoxic Activity

Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC₅₀ values of 3.55 µM and 7.14 µM, respectively.

Keywords: Arecaceae; Raphia vinifera; cytotoxicity; steroidal saponin.