Atypical Parkinsonism

The study will include a clinical, neuropsychological, oculomotor, food intake and environmental exposure assessment. Blood samples will be taken to constitute a library of plasma, DNA and serum. The harvesting of samples will be part of a subsequent study. Consent for possible post-mortem neuropathological analysis will be proposed.
All the patients accepting it will be followed by a 5-year longitudinal follow-up. The longitudinal follow-up bi-annual and then annual will include a clinical evaluation, a questionnaire of dependence and a questionnaire of monitoring of exposure to certain environmental factors
All controls must answer a questionnaire of environmental exposure factors, oculomotor test, and blood sample (3 collections: DNA, serum, plasma).

Clinical and biological exam

University Hospital of Guyana

University Hospital of Martinique

Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

Collection of :
administrative and socioeconomic data, medical consultation with video recording , recording oculomotor to the atypical

Collection of :
administrative and socioeconomic data, medical consultation with video recording , recording oculomotor to the atypical neuropsychological balance assessment ,
Clinical diagnostic criteria
Compilation of functional indicators of motor and cognitive autonomy and Collection of intercurrent medical events
Food and exposure questionnaire
Neuropsychological assessment
Recording of oculomotor movements and Post-mortem analysis
biological collection (plasma, DNA, serum)

Compilation of functional indicators of motor and cognitive autonomy and Collection of intercurrent medical events.
Collection of :
administrative and socioeconomic data, medical consultation with video recording , recording oculomotor to the atypical neuropsychological balance assessment ,

Neuropsychological assessment Food and exposure survey

Recording of oculomotor movements and Post-mortem analysis (sampling of blood and cutaneous biopsy to establish a collection of biological samples)

biological collection (plasma, DNA, serum)

Centre Hospitalier Universitaire de Pointe-a-Pitre

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.
This study has been designed as epidemiological, multicentric transversal descriptive and longitudinal prospective study with biological collection and post-mortem neuropathological sub-study of brain tissue.

annonacin/hallucinations

Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

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