aotus ericoides/hepatitis

Owl and cynomolgus monkeys were inoculated with hepatitis E virus (HEV) to compare disease models and produce antibody and virus. By immune electron microscopy (IEM), all six owl monkeys were shown to have serologic responses manifested by unusually high levels of anti-HEV at 6 months, but only

Sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis A virus (HM-175 or PA-33) were examined for histopathologic alterations. Preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts

The pathogenesis of hepatitis A virus (HAV) infection was studied in owl monkeys following oral administration of the wild-type HM-175 strain of HAV. Stools were collected daily and blood and pharyngeal swabs twice weekly for viral isolation, and animals were necropsied at various intervals after

Epidemiological studies have demonstrated the susceptibility of the owl monkey (Aotus trivirgatus) to hepatitis A virus, but have not shown an association between infection and histopathological or chemical evidence of liver disease. Therefore, 12 seronegative, colony-bred monkeys were inoculated

Several species of nonhuman primates have served as animal models for hepatitis A virus (HAV) infection and disease. This study was to determine the suitability of Aotus trivirgatus as an orally induced model for HAV infection and to reconfirm the owl monkey's susceptibility to the intravenous route

BACKGROUND Attempts to optimize DNA vaccines in mice include using different routes of administration and different formulations. It may be more relevant to human use to carry such studies out in nonhuman primates. Here we compare different approaches to delivery of a DNA vaccine against the

Cytokines IL-1-beta, IL-2, and TNF alpha were detected in occasional cells within portal inflammatory infiltrates beginning 3 weeks after oral inoculation of monkeys with HAV. The number of cells secreting those cytokines did not increase, and they were not of importance in the pathogenesis.

To determine the main causes of death in "owl monkeys" (Aotus nancymae and A. vociferans) in captivity, 115 necropsies were performed. According to the macroscopic findings and clinical data, results are as follow: acute lobular pneumonia (25.2%), chronic nephropathy (10.4%), acute catarrhal

Pseudotuberculosis caused by Yersinia enterocolitica was observed as an enzootic disease of the owl monkey (Aotus trivirgatus). A description is given of the natural disease and its successful reproduction in owl monkeys. The disease was characterized by purulent and necrotizing enteritis,