berbamine/infarction

Berbamine (BBM), a bisbenzylisoquinoline alkaloid from roots, bark, and stem of Berberis plant such as Berberis aristata has a wide range of pharmacological activities. However, the evidence for the cardioprotective effect of BBM is inadequate and the molecular mechanism of BBM remains unclear. This

The effects of berbamine (Ber, 10 mg.kg-1 iv) on ischemic ventricular tachyarrhythmia and electrophysiologic consequences in both normal and ischemic myocardia were studied in the open-chest dogs subjected to programmed electrical stimulation (PES) on 5-8 d after acute myocardial infarction. Its

Pretreatment of berbamine protects the heart from ischemia/reperfusion (I/R) injury. However it is unknown whether it has cardioprotection when given at the onset of reperfusion (postconditioning (PoC)), a protocol with more clinical impact. Autophagy is upregulated in I/R myocardium and exacerbates

BACKGROUND Berbamine, a natural compound from Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown. RESULTS Berbamine pretreatment from 10 to 100nmol/L concentration-dependently improved post-ischemic myocardial