berberrubine/sarcoma

The antitumor activity of several 13-alkyl-berberrubine and newly synthesized ester derivatives, using experimental tumors (S-180, NF sarcoma, Ehrlich carcinoma and L-1210) in mice was tested. For chemotherapeutic evaluation, the therapeutic indices and ratios were determined. Our present findings

The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total packed cell volume method. Berbine and tetrahydroberberine derivatives had no antitumor activity, but berberrubine (9-demethylberberine) and the ester derivatives of