Potassium citrate x 7days Off therapy x 7 days 500 mL low calorie orange juice beverage x 7 days 1000 mL low calorie orange juice beverage x 7 days Return to potassium citrate therapy Litholink urine collection to be performed after each 7 days treatment

500 mL low calorie orange juice beverage x 7 days 1000 mL low calorie orange juice beverage x 7 days Off therapy x 7 days Potassium citrate x 7days Continue on potassium citrate therapy Litholink urine collection to be performed after each 7 days treatment

Kidney Calculi

Kroger low calorie orange juice beverage will be consumed for 7 days followed by a 24 hour urine collection with Litholink to see if urine alkalization similar to potassium citrate can be achieved

Kroger low calorie orange juice beverage

Indiana University Health Methodist Hospital

Indiana University Health Physicians Urology

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With Kidney Stones

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With a History of Nephrolithiasis

The primary endpoint of interest will be the changes in urinary citrate while consuming Kroger low calorie orange juice beverage compared to potassium citrate therapy.

The primary endpoint of interest will be the changes in urinary pH while consuming Kroger low calorie orange juice beverage compared to potassium citrate therapy.

Tim Large

Principal Investigator

Indiana University

Group 1 kcit x 7 days ↓ Litholink on day 7
↓ off therapy x 7 days
↓ OJ 500 ML + 1.5L water /day x 7 days
↓ Litholink on day 7
↓ OJ 1000 ML + 1L water /day x 7 days
↓ Litholink on day 7 Return to kcit therapy
Group 2 OJ 500 ML + 1.5L water /day x 7 days ↓ Litholink on day 7
↓ OJ 1000 ML + 1L water /day x 7 days
↓ Litholink on day 7
↓ off therapy x 7 days
↓ kcit x 7 days
↓ Litholink on day 7 Continue on kcit therapy

Neutropenia

At least 2 capsules twice a day for 3 weeks

Sporanox

Lozanoc

St Vincent's Hospital

Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg

Steady-State Comparative Bioavailability Study in Patients Requiring Anti-Fungal Prophylaxis Comparing Twice a Day Dosing of Lozanoc® (Mayne) Regardless of Food With Sporanox® (Janssen) Under Fed Conditions

Individual patient data will not be made available

Mayne Pharma International Pty Ltd

One group will receive dry-cured pork ham of >10 months proteolysis (intervention product).
Intervention: Dietary intake Dry-cured pork ham contains high doses of bioactive peptides produced during more than 10 months of proteolysis.

The other group will receive cooked, uncured ham (placebo product). Intervention: Dietary intake. Cooked ham does not display bioactive peptides as they are produced during proteolysis of pork ham.

Hypertension

Cardiovascular Diseases

Dry-cured ham with reduced salt will be used in order to decrease the sodium intake that could affect blood pressure too. Such ham contains 25% lower salt than similar products on the market (3,7g vs 4,5g/100g).
Volunteers will receive 80g of cured pork ham daily for 28 consecutive days. They can eat the interventional product at any time of the day.

Spanish cured-pork ham

Volunteers will receive 100g of cooked pork ham daily for 28 consecutive days. They can eat the product (placebo product) at any time of the day.

cola/カリウム

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With Kidney Stones

Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg

Effects of Cured Pork Peptides on Blood Pressure & Cardiovascular Risk Factors

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