3 結果
Aldehydes generated during radical-induced lipid peroxidation, in particular 4-hydroxynonenal, are known to inhibit growth of certain cells. To extend our arguments that free radicals might be involved in the host response against malaria parasites we tested 26 carbonyls (n-alkanals, C6-C11;
Lymphoid and liver damage does not usually occur in Plasmodium vinckei-infected mice until parasitaemias reach 70-80 per cent and the mice are showing signs of illness. We report here that these changes can be induced in mice of healthy appearance and lower parasitaemia by injecting divicine or
Secretion of TNF from mouse peritoneal macrophages exposed to LPS in vitro was enhanced in the presence of H2O2 or sodium periodate. Neither of these agents induced release of TNF in the absence of LPS. Both iron chelators and free radical scavengers inhibited this enhanced secretion of TNF,