Two new sesquiterpene lactones 8alpha-(2',3'-dihydroxy-2'-methylbutanoyl)-15-desoxygoyazensolide and 16alpha-(1',2'-dihydroxy-1'-methylpropyl)-eremantholide have been identified as constituents of Eremanthus argenteus aerial parts. In addition, two known sesquiterpene lactones and three flavonoids